Age dependent systemic exposure to inhaled salbutamol

Klaus Bønnelykke; Jakob Jessing Jespersen; Hans Bisgaard

doi:10.1111/j.1365-2125.2007.02868.x

Age dependent systemic exposure to inhaled salbutamol

Klaus Bønnelykke, Jakob Jessing Jespersen, Hans Bisgaard

Allergi, Hud- og Kønssygdomme

8 Citationer (Scopus)

Abstract

AIMS: To determine the effect of age on systemic exposure to inhaled salbutamol in children.

METHODS: Fifty-eight asthmatic children, aged 3-16 years, inhaled 400 microg of salbutamol from a pressurized metered dose inhaler with spacer. The 20 min serum profile was analyzed.

RESULTS: Prescribing a dose on a microg kg(-1) basis caused reduced systemic exposure in young children (Y) compared with older children (O) (C(max-microg kg(-1)-adjusted) Y : O ratio (95%CI) = 0.55 (0.47, 0.65)) whereas a fixed nominal dose irrespective of age caused increased exposure in young children (C(max) Y : O ratio (95%CI) = 1.7 (1.3, 2.2)).

CONCLUSIONS: For similar systemic exposure, dosing should be adjusted to age or size but not on a fixed microg kg(-1) basis, which may lead to unnecessary suboptimal dosing.

Originalsprog	Engelsk
Tidsskrift	British Journal of Clinical Pharmacology
Vol/bind	64
Udgave nummer	2
Sider (fra-til)	241-4
Antal sider	4
ISSN	0306-5251
DOI	https://doi.org/10.1111/j.1365-2125.2007.02868.x
Status	Udgivet - aug. 2007

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10.1111/j.1365-2125.2007.02868.x

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title = "Age dependent systemic exposure to inhaled salbutamol",

abstract = "AIMS: To determine the effect of age on systemic exposure to inhaled salbutamol in children.METHODS: Fifty-eight asthmatic children, aged 3-16 years, inhaled 400 microg of salbutamol from a pressurized metered dose inhaler with spacer. The 20 min serum profile was analyzed.RESULTS: Prescribing a dose on a microg kg(-1) basis caused reduced systemic exposure in young children (Y) compared with older children (O) (C(max-microg kg(-1)-adjusted) Y : O ratio (95%CI) = 0.55 (0.47, 0.65)) whereas a fixed nominal dose irrespective of age caused increased exposure in young children (C(max) Y : O ratio (95%CI) = 1.7 (1.3, 2.2)).CONCLUSIONS: For similar systemic exposure, dosing should be adjusted to age or size but not on a fixed microg kg(-1) basis, which may lead to unnecessary suboptimal dosing.",

keywords = "Administration, Inhalation, Adolescent, Age Factors, Albuterol, Asthma, Bronchodilator Agents, Child, Child, Preschool, Dose-Response Relationship, Drug, Female, Humans, Lung, Male",

author = "Klaus B{\o}nnelykke and Jespersen, {Jakob Jessing} and Hans Bisgaard",

year = "2007",

month = aug,

doi = "10.1111/j.1365-2125.2007.02868.x",

language = "English",

volume = "64",

pages = "241--4",

journal = "British Journal of Clinical Pharmacology",

issn = "0306-5251",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

TY - JOUR

T1 - Age dependent systemic exposure to inhaled salbutamol

AU - Bønnelykke, Klaus

AU - Jespersen, Jakob Jessing

AU - Bisgaard, Hans

PY - 2007/8

Y1 - 2007/8

N2 - AIMS: To determine the effect of age on systemic exposure to inhaled salbutamol in children.METHODS: Fifty-eight asthmatic children, aged 3-16 years, inhaled 400 microg of salbutamol from a pressurized metered dose inhaler with spacer. The 20 min serum profile was analyzed.RESULTS: Prescribing a dose on a microg kg(-1) basis caused reduced systemic exposure in young children (Y) compared with older children (O) (C(max-microg kg(-1)-adjusted) Y : O ratio (95%CI) = 0.55 (0.47, 0.65)) whereas a fixed nominal dose irrespective of age caused increased exposure in young children (C(max) Y : O ratio (95%CI) = 1.7 (1.3, 2.2)).CONCLUSIONS: For similar systemic exposure, dosing should be adjusted to age or size but not on a fixed microg kg(-1) basis, which may lead to unnecessary suboptimal dosing.

AB - AIMS: To determine the effect of age on systemic exposure to inhaled salbutamol in children.METHODS: Fifty-eight asthmatic children, aged 3-16 years, inhaled 400 microg of salbutamol from a pressurized metered dose inhaler with spacer. The 20 min serum profile was analyzed.RESULTS: Prescribing a dose on a microg kg(-1) basis caused reduced systemic exposure in young children (Y) compared with older children (O) (C(max-microg kg(-1)-adjusted) Y : O ratio (95%CI) = 0.55 (0.47, 0.65)) whereas a fixed nominal dose irrespective of age caused increased exposure in young children (C(max) Y : O ratio (95%CI) = 1.7 (1.3, 2.2)).CONCLUSIONS: For similar systemic exposure, dosing should be adjusted to age or size but not on a fixed microg kg(-1) basis, which may lead to unnecessary suboptimal dosing.

KW - Administration, Inhalation

KW - Adolescent

KW - Age Factors

KW - Albuterol

KW - Asthma

KW - Bronchodilator Agents

KW - Child

KW - Child, Preschool

KW - Dose-Response Relationship, Drug

KW - Female

KW - Humans

KW - Lung

KW - Male

U2 - 10.1111/j.1365-2125.2007.02868.x

DO - 10.1111/j.1365-2125.2007.02868.x

M3 - Journal article

C2 - 17335545

SN - 0306-5251

VL - 64

SP - 241

EP - 244

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 2

ER -

Age dependent systemic exposure to inhaled salbutamol

Abstract

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