Age dependence of rat liver function measurements

A Fischer-Nielsen, H E Poulsen, B A Hansen, N Tygstrup, Susanne Keiding

8 Citationer (Scopus)

Abstract

Changes in the galactose elimination capacity, the capacity of urea-N synthesis and antipyrine clearance were studied in male Wistar rats at the age of 8, 20 and 44 weeks. Further, liver tissue concentrations of microsomal cytochrome P-450, microsomal protein and glutathione were measured. All liver function measurements increased from the age of 8 to 44 weeks when expressed in absolute values. In relation to body weight, these function measurements were unchanged or reduced from week 8 to week 20. At week 44, galactose elimination capacity and capacity of urea-N synthesis related to body weight were increased by 10% and 36%, respectively, and antipyrine plasma clearance was reduced to 50%. Liver tissue concentrations of microsomal cytochrome P-450 and microsomal protein increased with age when expressed in absolute values, but were unchanged per g liver, i.e., closely related to liver weight in the age range studied. Glutathione showed an increase of 35% from 8 to 44 weeks of age expressed per g liver. Careful age matching of control animals is important for experimental rat studies.

OriginalsprogEngelsk
TidsskriftJournal of Hepatology
Vol/bind9
Udgave nummer2
Sider (fra-til)190-7
Antal sider8
ISSN0168-8278
StatusUdgivet - sep. 1989

Fingeraftryk

Dyk ned i forskningsemnerne om 'Age dependence of rat liver function measurements'. Sammen danner de et unikt fingeraftryk.

Citationsformater