Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Affective episodes in recently diagnosed patients with bipolar disorder associated with altered working memory-related prefrontal cortex activity: A longitudinal fMRI study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Incomplete systematic review and meta-analysis on statin use and depression risk - A commentary

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Treatment patterns in patients with treatment-resistant depression in Danish patients with major depressive disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Predictors of treatment outcomes for trauma-affected refugees - results from two randomised trials

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A Rasch-based validity study of the Harvard Trauma Questionnaire

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Incomplete systematic review and meta-analysis on statin use and depression risk - A commentary

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Primary prevention of depression: An umbrella review of controlled interventions

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Autism comorbidities show elevated female-to-male odds ratios and are associated with the age of first autism diagnosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Risk of depression after diagnostic prostate cancer workup - A nationwide, registry-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

INTRODUCTION: Bipolar disorder (BD) is often accompanied by trait-related cognitive impairments, but it is unclear which neurocircuitry abnormalities give rise to these impairments and whether neurocircuitry differences are exacerbated with illness progression. This longitudinal fMRI study of recently diagnosed BD patients investigates whether aberrant working memory (WM) related activity in the cognitive control network is accentuated by new affective episodes.

METHODS: Forty-seven recently diagnosed BD patients in full or partial remission and 38 healthy controls were assessed with neurocognitive tests and fMRI during the performance of a verbal n-back WM task at baseline and follow-up (15.4 months in average).

RESULTS: Patients showed WM-related hypo-activity in dorsal prefrontal cortex (dPFC) and impaired cognitive function within attention and psychomotor speed, WM and executive function, and verbal learning and memory compared to controls at baseline. During the follow-up period, 26 patients experienced at least one affective episode (BD+), while 21 remained in remission (BD-). There was no deterioration in cognitive performance in BD+ compared to BD- patients. Nevertheless, BD+ displayed increased WM-related dPFC activity at follow-up compared with BD- patients. This change in dPFC response was independent of mood symptoms and medication.

LIMITATIONS: The study did not account for type or frequency of affective episodes.

CONCLUSION: The study identifies cognitive impairment and WM-related hypo-activity in dPFC early during the course of BD. Increased high-load WM related dPFC activity over the follow-up period in BD+ versus BD- patients in the absence of changes in cognitive performance may reflect an episode-related reduction in PFC efficiency.

OriginalsprogEngelsk
TidsskriftJournal of Affective Disorders
Vol/bind295
Sider (fra-til)647-656
Antal sider10
ISSN0165-0327
DOI
StatusE-pub ahead of print - 4 sep. 2021

Bibliografisk note

Copyright © 2021. Published by Elsevier B.V.

ID: 68338653