Aetiology and treatment of chronic heart failure with reduced left ventricular function

Anders Hostrup Larsen; Trine Kiilerich Lauridsen; Julie Vishram-Nielsen; Henrik Vase; Søren Vraa; Emil Wolsk; Anders Barasa; Helle Søholm; Lars Køber; Nadia Paarup Dridi

doi:10.61409/V05240339

Aetiology and treatment of chronic heart failure with reduced left ventricular function

Anders Hostrup Larsen, Trine Kiilerich Lauridsen, Julie Vishram-Nielsen, Henrik Vase, Søren Vraa, Emil Wolsk, Anders Barasa, Helle Søholm, Lars Køber, Nadia Paarup Dridi

Abstract

Heart failure with reduced ejection fraction is a syndrome consisting of symptoms (dyspnoea, fatigue, swelling) and/or signs of congestion (pulmonary crackles, oedema). It is caused by structural and/or functional pathologies, most commonly ischaemic heart disease, entailing elevated cardiac filling pressures and can result in low cardiac output. Medical treatment has evolved during the recent decades as outlined in this review, and a 4-pillar treatment strategy is recommended including a renin-angiotensin-aldosterone system blocker or sacubitril/valsartan, a betablocker, a mineralocorticoid antagonist, and an SGLT2 inhibitor.

Bidragets oversatte titel	Not Available
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	186
Udgave nummer	42
ISSN	0041-5782
DOI	https://doi.org/10.61409/V05240339
Status	Udgivet - 14 okt. 2024

Emneord

Humans
Heart Failure/drug therapy
Mineralocorticoid Receptor Antagonists/therapeutic use
Adrenergic beta-Antagonists/therapeutic use
Chronic Disease
Ventricular Dysfunction, Left/drug therapy
Angiotensin Receptor Antagonists/therapeutic use
Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
Stroke Volume
Angiotensin-Converting Enzyme Inhibitors/therapeutic use

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10.61409/V05240339

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title = "Aetiology and treatment of chronic heart failure with reduced left ventricular function",

abstract = "Heart failure with reduced ejection fraction is a syndrome consisting of symptoms (dyspnoea, fatigue, swelling) and/or signs of congestion (pulmonary crackles, oedema). It is caused by structural and/or functional pathologies, most commonly ischaemic heart disease, entailing elevated cardiac filling pressures and can result in low cardiac output. Medical treatment has evolved during the recent decades as outlined in this review, and a 4-pillar treatment strategy is recommended including a renin-angiotensin-aldosterone system blocker or sacubitril/valsartan, a betablocker, a mineralocorticoid antagonist, and an SGLT2 inhibitor.",

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author = "Larsen, {Anders Hostrup} and Lauridsen, {Trine Kiilerich} and Julie Vishram-Nielsen and Henrik Vase and S{\o}ren Vraa and Emil Wolsk and Anders Barasa and Helle S{\o}holm and Lars K{\o}ber and Dridi, {Nadia Paarup}",

note = "Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

year = "2024",

month = oct,

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language = "Dansk",

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TY - JOUR

T1 - Aetiology and treatment of chronic heart failure with reduced left ventricular function

AU - Larsen, Anders Hostrup

AU - Lauridsen, Trine Kiilerich

AU - Vishram-Nielsen, Julie

AU - Vase, Henrik

AU - Vraa, Søren

AU - Wolsk, Emil

AU - Barasa, Anders

AU - Søholm, Helle

AU - Køber, Lars

AU - Dridi, Nadia Paarup

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2024/10/14

Y1 - 2024/10/14

N2 - Heart failure with reduced ejection fraction is a syndrome consisting of symptoms (dyspnoea, fatigue, swelling) and/or signs of congestion (pulmonary crackles, oedema). It is caused by structural and/or functional pathologies, most commonly ischaemic heart disease, entailing elevated cardiac filling pressures and can result in low cardiac output. Medical treatment has evolved during the recent decades as outlined in this review, and a 4-pillar treatment strategy is recommended including a renin-angiotensin-aldosterone system blocker or sacubitril/valsartan, a betablocker, a mineralocorticoid antagonist, and an SGLT2 inhibitor.

AB - Heart failure with reduced ejection fraction is a syndrome consisting of symptoms (dyspnoea, fatigue, swelling) and/or signs of congestion (pulmonary crackles, oedema). It is caused by structural and/or functional pathologies, most commonly ischaemic heart disease, entailing elevated cardiac filling pressures and can result in low cardiac output. Medical treatment has evolved during the recent decades as outlined in this review, and a 4-pillar treatment strategy is recommended including a renin-angiotensin-aldosterone system blocker or sacubitril/valsartan, a betablocker, a mineralocorticoid antagonist, and an SGLT2 inhibitor.

KW - Humans

KW - Heart Failure/drug therapy

KW - Mineralocorticoid Receptor Antagonists/therapeutic use

KW - Adrenergic beta-Antagonists/therapeutic use

KW - Chronic Disease

KW - Ventricular Dysfunction, Left/drug therapy

KW - Angiotensin Receptor Antagonists/therapeutic use

KW - Sodium-Glucose Transporter 2 Inhibitors/therapeutic use

KW - Stroke Volume

KW - Angiotensin-Converting Enzyme Inhibitors/therapeutic use

UR - http://www.scopus.com/inward/record.url?scp=85209479845&partnerID=8YFLogxK

U2 - 10.61409/V05240339

DO - 10.61409/V05240339

M3 - Review

C2 - 39531028

SN - 0041-5782

VL - 186

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 42

ER -

Aetiology and treatment of chronic heart failure with reduced left ventricular function

Abstract

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