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Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database

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Engjom, Trond ; Nordaas, Ingrid Kvåle ; Tjora, Erling ; Dimcevski, Georg ; Haldorsen, Ingfrid Salvesen ; Olesen, Søren Schou ; Drewes, Asbjørn Mohr ; Zviniene, Kristina ; Barauskas, Giedrus ; Riis Jespersen, Hans Søe ; Jensen, Nanna ; Borch, Anders ; Nøjgaard, Camilla ; Novovic, Srdan ; Kardasheva, Svetlana S ; Okhlobystin, Alexey ; Hauge, Truls ; Waage, Anne ; Frøkjær, Jens Brøndum. / Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis : A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database. I: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2021 ; Bind 21, Nr. 4. s. 688-697.

Bibtex

@article{88708f930cc14052a25574c81c82fd7e,
title = "Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database",
abstract = "OBJECTIVES: The relation between aetiology and structural changes of the pancreas in patients with chronic pancreatitis (CP) is not fully understood. Earlier studies are limited by focusing on selected factors in studies of limited sample size. We aimed to use a large dataset to explore associations between aetiology and pancreatic morphology in CP.METHODS: Subjects with definite or probable CP according to the M-ANNHEIM diagnostic criteria were included in this multicentre cross-sectional observational study and assessed using a standardized and validated CP imaging system. We performed multivariate logistic regression to analyse if aetiological factors adjusted for covariates were independently associated with morphological pancreatic features.RESULTS: We included 959 patients (66% males). Mean (SD) age was 55 (14) years. Pancreatic structural changes were found in 94% of the subjects: 67% had calcifications, 59% main pancreatic duct dilatation, 33% pseudo-cysts and 22% pancreatic atrophy. Alcohol abuse was independently associated with pancreatic calcifications (odds ratio (OR, [95% CI]); 1.61, [1.09, 2.37]) and focal acute pancreatitis (OR; 2.13, [1.27, 3.56]), whereas smoking was independently associated with more severe calcifications (OR; 2.09, [1.34, 3.27]) and involvement of the whole gland (OR; 2.29, [1.61, 3.28]). Disease duration was positively associated with calcifications (OR; (per year) 1.05 [1.02, 1.08]) and pancreatic atrophy (OR; 1.05 [1.02, 1.08]) and negatively associated with focal acute pancreatitis (OR 0.91, [0.87, 0.95] and pseudo cysts (OR; 0.96, [0.93, 0.98]).CONCLUSION: In this large-scale study, etiological risk factors and disease duration in CP were independently associated with specific structural pancreatic imaging changes.",
keywords = "Aetiology, Chronic pancreatitis, Imaging, Risk factor",
author = "Trond Engjom and Nordaas, {Ingrid Kv{\aa}le} and Erling Tjora and Georg Dimcevski and Haldorsen, {Ingfrid Salvesen} and Olesen, {S{\o}ren Schou} and Drewes, {Asbj{\o}rn Mohr} and Kristina Zviniene and Giedrus Barauskas and {Riis Jespersen}, {Hans S{\o}e} and Nanna Jensen and Anders Borch and Camilla N{\o}jgaard and Srdan Novovic and Kardasheva, {Svetlana S} and Alexey Okhlobystin and Truls Hauge and Anne Waage and Fr{\o}kj{\ae}r, {Jens Br{\o}ndum}",
note = "Copyright {\textcopyright} 2021 IAP and EPC. Published by Elsevier B.V. All rights reserved.",
year = "2021",
month = jun,
doi = "10.1016/j.pan.2021.02.023",
language = "English",
volume = "21",
pages = "688--697",
journal = "Pancreatology",
issn = "1424-3903",
publisher = "S./Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis

T2 - A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database

AU - Engjom, Trond

AU - Nordaas, Ingrid Kvåle

AU - Tjora, Erling

AU - Dimcevski, Georg

AU - Haldorsen, Ingfrid Salvesen

AU - Olesen, Søren Schou

AU - Drewes, Asbjørn Mohr

AU - Zviniene, Kristina

AU - Barauskas, Giedrus

AU - Riis Jespersen, Hans Søe

AU - Jensen, Nanna

AU - Borch, Anders

AU - Nøjgaard, Camilla

AU - Novovic, Srdan

AU - Kardasheva, Svetlana S

AU - Okhlobystin, Alexey

AU - Hauge, Truls

AU - Waage, Anne

AU - Frøkjær, Jens Brøndum

N1 - Copyright © 2021 IAP and EPC. Published by Elsevier B.V. All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - OBJECTIVES: The relation between aetiology and structural changes of the pancreas in patients with chronic pancreatitis (CP) is not fully understood. Earlier studies are limited by focusing on selected factors in studies of limited sample size. We aimed to use a large dataset to explore associations between aetiology and pancreatic morphology in CP.METHODS: Subjects with definite or probable CP according to the M-ANNHEIM diagnostic criteria were included in this multicentre cross-sectional observational study and assessed using a standardized and validated CP imaging system. We performed multivariate logistic regression to analyse if aetiological factors adjusted for covariates were independently associated with morphological pancreatic features.RESULTS: We included 959 patients (66% males). Mean (SD) age was 55 (14) years. Pancreatic structural changes were found in 94% of the subjects: 67% had calcifications, 59% main pancreatic duct dilatation, 33% pseudo-cysts and 22% pancreatic atrophy. Alcohol abuse was independently associated with pancreatic calcifications (odds ratio (OR, [95% CI]); 1.61, [1.09, 2.37]) and focal acute pancreatitis (OR; 2.13, [1.27, 3.56]), whereas smoking was independently associated with more severe calcifications (OR; 2.09, [1.34, 3.27]) and involvement of the whole gland (OR; 2.29, [1.61, 3.28]). Disease duration was positively associated with calcifications (OR; (per year) 1.05 [1.02, 1.08]) and pancreatic atrophy (OR; 1.05 [1.02, 1.08]) and negatively associated with focal acute pancreatitis (OR 0.91, [0.87, 0.95] and pseudo cysts (OR; 0.96, [0.93, 0.98]).CONCLUSION: In this large-scale study, etiological risk factors and disease duration in CP were independently associated with specific structural pancreatic imaging changes.

AB - OBJECTIVES: The relation between aetiology and structural changes of the pancreas in patients with chronic pancreatitis (CP) is not fully understood. Earlier studies are limited by focusing on selected factors in studies of limited sample size. We aimed to use a large dataset to explore associations between aetiology and pancreatic morphology in CP.METHODS: Subjects with definite or probable CP according to the M-ANNHEIM diagnostic criteria were included in this multicentre cross-sectional observational study and assessed using a standardized and validated CP imaging system. We performed multivariate logistic regression to analyse if aetiological factors adjusted for covariates were independently associated with morphological pancreatic features.RESULTS: We included 959 patients (66% males). Mean (SD) age was 55 (14) years. Pancreatic structural changes were found in 94% of the subjects: 67% had calcifications, 59% main pancreatic duct dilatation, 33% pseudo-cysts and 22% pancreatic atrophy. Alcohol abuse was independently associated with pancreatic calcifications (odds ratio (OR, [95% CI]); 1.61, [1.09, 2.37]) and focal acute pancreatitis (OR; 2.13, [1.27, 3.56]), whereas smoking was independently associated with more severe calcifications (OR; 2.09, [1.34, 3.27]) and involvement of the whole gland (OR; 2.29, [1.61, 3.28]). Disease duration was positively associated with calcifications (OR; (per year) 1.05 [1.02, 1.08]) and pancreatic atrophy (OR; 1.05 [1.02, 1.08]) and negatively associated with focal acute pancreatitis (OR 0.91, [0.87, 0.95] and pseudo cysts (OR; 0.96, [0.93, 0.98]).CONCLUSION: In this large-scale study, etiological risk factors and disease duration in CP were independently associated with specific structural pancreatic imaging changes.

KW - Aetiology

KW - Chronic pancreatitis

KW - Imaging

KW - Risk factor

UR - http://www.scopus.com/inward/record.url?scp=85102106601&partnerID=8YFLogxK

U2 - 10.1016/j.pan.2021.02.023

DO - 10.1016/j.pan.2021.02.023

M3 - Journal article

C2 - 33707113

VL - 21

SP - 688

EP - 697

JO - Pancreatology

JF - Pancreatology

SN - 1424-3903

IS - 4

ER -

ID: 64229125