Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Adverse Events during Immunotherapy against Grass Pollen-Induced Allergic Rhinitis - Differences between Subcutaneous and Sublingual Treatment

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Drug-related challenges following primary total hip and knee arthroplasty

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Validation of registration of pharmacological treatment in the Danish Hip and Knee Arthroplasty Registers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Airway gene expression identifies subtypes of type 2 inflammation in severe asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Socioeconomic biases in asthma control and specialist referral of possible severe asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Airway hyperresponsiveness to inhaled mannitol identifies a cluster of non-eosinophilic asthma patients with high symptom burden

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Allergic rhinitis triggered by grass pollen is a common disease, affecting millions of people worldwide. Treatment consists of symptom-alleviating drugs, such as topical corticosteroids or antihistamines. Another option is potentially curative immunotherapy, currently available as sublingual and subcutaneous treatment. We investigated the potential differences in the prevalence and severity of adverse events related to subcutaneous and sublingual immunotherapy against grass pollen-induced allergic rhinitis. A thorough literature search was performed using PubMed and EMBASE. The findings were compared with the available summaries of product characteristics and with commercial pharmacology databases (Micromedex). The majority of available safety data originates from registered products of standardized allergens. A surprisingly large percentage of drugs, especially those used in the United States, have no systematically collected safety data. No sufficiently powered randomized trials comparing sublingual and subcutaneous immunotherapy were available, but general safety assessments indicate that sublingual tablet treatment is safer than subcutaneous treatment. Not all commonly used immunotherapy drugs are officially registered and not all have systematically collected safety data. This is especially true for older drugs used in the United Stages. In contrast, newer drugs that have undergone extensive clinical testing have better documentation, but unified collection of safety data is still lacking. Considering the evidence available, most drugs elicit similar side effects from the same organ systems, and symptoms from the sublingual drug classes are probably less severe. However, a head-to-head comparison of safety and efficacy is lacking. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftBasic & clinical pharmacology & toxicology
Vol/bind117
Udgave nummer2
Sider (fra-til)73-84
Antal sider11
ISSN1742-7843
DOI
StatusUdgivet - aug. 2015

ID: 45344854