Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Advancing the management of Obstructive Airways Diseases through Translational Research

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Bronchoscopic mucosal cryobiopsies as a method for studying airway disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Determinants of low risk of asthma exacerbation during pregnancy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. High breast milk IL-1β level is associated with reduced risk of childhood eczema

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Dynamics of plasma levels of specific IgE in chlorhexidine allergic patients with and without accidental re-exposure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Development of the International Severe Asthma Registry (ISAR): a modified Delphi study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Bronchoscopic mucosal cryobiopsies as a method for studying airway disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Differentiation of adult severe asthma from difficult-to-treat asthma - Outcomes of a systematic assessment protocol

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Validation of ATS clinical practice guideline cut-points for FeNO in asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. FeNO-based asthma management results in faster improvement of airway hyperresponsiveness

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Obstructive airways diseases (OAD) represent a huge burden of illness worldwide, and in spite of the development of effective therapies, significant morbidity and mortality related to asthma and COPD still remains. Over the past decade, our understanding of OAD has improved vastly, and novel treatments have evolved. This evolution is the result of successful translational research, which has connected clinical presentations of OAD and underlying disease mechanisms, thereby enabling the development of targeted treatments. The next challenge of translational research will be to position these novel treatments for OAD for optimal clinical use. At the same time, there is great potential in these treatments providing even better insights into disease mechanisms in OAD, by studying the effects of blocking individual immunological pathways. To optimise this potential, there is a need to ensure that translational aspects are added to randomised clinical trials, as well as Real World studies, but also to use other trial designs such as platform studies, which allow for simultaneous assessment of different interventions. Furthermore, demonstrating clinical impact, i.e. research translation, is an increasingly important component of successful translational research. This review outlines concepts of translational research, exemplifying how translational research has moved management of Obstructive Airways Diseases into the next century, with the introduction of targeted, individualised therapy. Furthermore, the review describes how these therapies may be used as research tools, to further our understanding of disease mechanisms in OAD, through translational, mechanistic studies. We underline the current need for implementing basic immunological concepts into clinical care, in order to optimise the use of novel targeted treatments, and to further the clinical understanding of disease mechanisms. Finally, potential barriers to adoption of novel targeted therapies into routine practice are described, and how these may be overcome. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Vol/bind48
Udgave nummer5
Sider (fra-til)493-501
Antal sider9
ISSN0954-7894
DOI
StatusUdgivet - maj 2018

ID: 52692031