Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Advanced age is a risk factor for proximal adenoma recurrence following colonoscopy and polypectomy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Associations between blood cultures after surgery for colorectal cancer and long-term oncological outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Closure of the fascial defect during laparoscopic umbilical hernia repair: a randomized clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Functional outcomes from a randomized trial of early closure of temporary ileostomy after rectal excision for cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prospective observational cohort study on grading the severity of postoperative complications in global surgery research

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Colorectal Cancer in Individuals With Familial Adenomatous Polyposis, Based on Analysis of the Danish Polyposis Registry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Dødeligheden efter akut laparotomi kan reduceres

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The impact of blood type on transfusion after major emergency abdominal surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Knowledge of risk factors for recurrence of colorectal adenomas may identify patients who could benefit from individual surveillance strategies. The aim of this study was to identify risk factors for recurrence of colorectal adenomas in a high-risk population.

METHODS: Data were used from a randomized clinical trial that showed no effect of aspirin-calcitriol-calcium treatment on colorectal adenoma recurrence. Patients at high risk of colorectal cancer who had one or more sporadic colorectal adenomas removed during colonoscopy were followed up for 3 years. Independent risk factors associated with recurrence and characteristics of recurrent adenomas were investigated in a generalized linear model.

RESULTS: After 3 years, the recurrence rate was 25·8 per cent in 427 patients. For younger subjects (aged 50 years or less), the recurrence rate was 19 per cent; 18 of 20 recurrent adenomas were located in the distal part of the colon. For older subjects (aged over 70 years), the recurrence rate was 35 per cent, and 16 of 25 recurrent adenomas were in the proximal colon. Age (odds ratio (OR) 1·04, 95 per cent c.i. 1·01 to 1·07) and number of adenomas (OR 1·27, 1·11 to 1·46) at the time of inclusion in the study were independent risk factors for recurrence.

CONCLUSION: In contrast to current guidelines, advanced age is not a reason to discontinue adenoma surveillance in patients with an anticipated live expectancy in which recurrence can arise.

OriginalsprogEngelsk
TidsskriftThe British journal of surgery
Vol/bind130
Udgave nummer2
Sider (fra-til)e100-e105
ISSN0007-1323
DOI
StatusUdgivet - jan. 2016

ID: 45900824