Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group

A F Attanasio, S W Lamberts, A M Matranga, M A Birkett, P C Bates, N K Valk, J Hilsted, Birgit Bengtsson, C J Strasburger

    381 Citationer (Scopus)

    Abstract

    The onset of adult GH deficiency may be during either adulthood (AO) or childhood (CO), but potential differences have not previously been examined. In this study the baseline and GH therapy (12.5 micrograms/kg per day) data from CO (n = 74; mean age 29 yr) and AO (n = 99; mean age 44 yr) GH-deficient adult patients have been compared. The first 6 months comprised randomized, double-blind treatment with GH or placebo, then all patients were GH-treated for a further 12 months. At baseline the height, body weight, body mass index, lean body mass, and waist/hip ratio of AO patients were significantly (P
    OriginalsprogEngelsk
    TidsskriftThe Journal of clinical endocrinology and metabolism
    Vol/bind82
    Udgave nummer1
    Sider (fra-til)82-8
    Antal sider7
    ISSN0021-972X
    StatusUdgivet - jan. 1997

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