Harvard
Lunen, TB, Johansson, PI, Jensen, LP, Homburg, KM, Roeder, OC
, Lonn, L, Secher, NH, Helgstrand, U, Carstensen, M, Jensen, KB, Lange, T
, Sillesen, H, Swiatek, F & Nielsen, HB 2018, '
Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery: a prospective, single-blinded, randomised study'
Transfusion medicine (Oxford, England), bind 28, nr. 5, s. 386-391.
https://doi.org/10.1111/tme.12540
APA
Lunen, T. B., Johansson, P. I., Jensen, L. P., Homburg, K. M., Roeder, O. C.
, Lonn, L., ... Nielsen, H. B. (2018).
Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery: a prospective, single-blinded, randomised study.
Transfusion medicine (Oxford, England),
28(5), 386-391.
https://doi.org/10.1111/tme.12540
CBE
Lunen TB, Johansson PI, Jensen LP, Homburg KM, Roeder OC
, Lonn L, Secher NH, Helgstrand U, Carstensen M, Jensen KB, Lange T
, Sillesen H, Swiatek F, Nielsen HB. 2018.
Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery: a prospective, single-blinded, randomised study.
Transfusion medicine (Oxford, England). 28(5):386-391.
https://doi.org/10.1111/tme.12540
MLA
Vancouver
Author
Lunen, T B ; Johansson, P I ; Jensen, L P ; Homburg, K M ; Roeder, O C
; Lonn, L ; Secher, N H ; Helgstrand, U ; Carstensen, M ; Jensen, K B ; Lange, T
; Sillesen, H ; Swiatek, F ; Nielsen, H B. /
Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery : a prospective, single-blinded, randomised study. I:
Transfusion medicine (Oxford, England). 2018 ; Bind 28, Nr. 5. s. 386-391.
Bibtex
@article{531527cca9af4078a4f16c82ca076e91,
title = "Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery: a prospective, single-blinded, randomised study",
abstract = "BACKGROUND: In patients undergoing open surgery for a ruptured abdominal aortic aneurysm (rAAA), survivors demonstrate a high platelet count, and proactive administration of platelets (and fresh frozen plasma) appears to influence mortality.OBJECTIVES: This trial investigated the effect of platelets administered before transport to surgery.METHODS: In a prospective study design, patients were randomised to receive platelets (intervention; n = 61) or no platelets (control; n = 61) before transport to vascular surgery from 11 local hospitals. The study was terminated when one of the vascular surgical centres implemented endovascular repair for rAAA patients.RESULTS: Thirty days after surgery, mortality was 36{\%} for patients with intervention vs 31{\%} for controls (P = 0·32). Post-operative thrombotic events (14 vs 15; P = 0·69), renal failure (11 vs 10; P = 0·15) and pulmonary insufficiency (34 vs 39; P = 0·15) were similar in the two groups of patients. No adverse reactions to platelet administration were observed. In addition, length of stay in the intensive care unit was unaffected by intervention.CONCLUSIONS: For patients planned for open repair of a rAAA, we observed no significant effect of early administration of platelets with regard to post-operative complications and stay in the ICU or in hospital and also no significant effect on mortality.",
author = "Lunen, {T B} and Johansson, {P I} and Jensen, {L P} and Homburg, {K M} and Roeder, {O C} and L Lonn and Secher, {N H} and U Helgstrand and M Carstensen and Jensen, {K B} and T Lange and H Sillesen and F Swiatek and Nielsen, {H B}",
note = "{\circledC} 2018 British Blood Transfusion Society.",
year = "2018",
month = "10",
doi = "10.1111/tme.12540",
language = "English",
volume = "28",
pages = "386--391",
journal = "Transfusion Medicine",
issn = "0958-7578",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "5",
}
RIS
TY - JOUR
T1 - Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery
T2 - a prospective, single-blinded, randomised study
AU - Lunen, T B
AU - Johansson, P I
AU - Jensen, L P
AU - Homburg, K M
AU - Roeder, O C
AU - Lonn, L
AU - Secher, N H
AU - Helgstrand, U
AU - Carstensen, M
AU - Jensen, K B
AU - Lange, T
AU - Sillesen, H
AU - Swiatek, F
AU - Nielsen, H B
N1 - © 2018 British Blood Transfusion Society.
PY - 2018/10
Y1 - 2018/10
N2 - BACKGROUND: In patients undergoing open surgery for a ruptured abdominal aortic aneurysm (rAAA), survivors demonstrate a high platelet count, and proactive administration of platelets (and fresh frozen plasma) appears to influence mortality.OBJECTIVES: This trial investigated the effect of platelets administered before transport to surgery.METHODS: In a prospective study design, patients were randomised to receive platelets (intervention; n = 61) or no platelets (control; n = 61) before transport to vascular surgery from 11 local hospitals. The study was terminated when one of the vascular surgical centres implemented endovascular repair for rAAA patients.RESULTS: Thirty days after surgery, mortality was 36% for patients with intervention vs 31% for controls (P = 0·32). Post-operative thrombotic events (14 vs 15; P = 0·69), renal failure (11 vs 10; P = 0·15) and pulmonary insufficiency (34 vs 39; P = 0·15) were similar in the two groups of patients. No adverse reactions to platelet administration were observed. In addition, length of stay in the intensive care unit was unaffected by intervention.CONCLUSIONS: For patients planned for open repair of a rAAA, we observed no significant effect of early administration of platelets with regard to post-operative complications and stay in the ICU or in hospital and also no significant effect on mortality.
AB - BACKGROUND: In patients undergoing open surgery for a ruptured abdominal aortic aneurysm (rAAA), survivors demonstrate a high platelet count, and proactive administration of platelets (and fresh frozen plasma) appears to influence mortality.OBJECTIVES: This trial investigated the effect of platelets administered before transport to surgery.METHODS: In a prospective study design, patients were randomised to receive platelets (intervention; n = 61) or no platelets (control; n = 61) before transport to vascular surgery from 11 local hospitals. The study was terminated when one of the vascular surgical centres implemented endovascular repair for rAAA patients.RESULTS: Thirty days after surgery, mortality was 36% for patients with intervention vs 31% for controls (P = 0·32). Post-operative thrombotic events (14 vs 15; P = 0·69), renal failure (11 vs 10; P = 0·15) and pulmonary insufficiency (34 vs 39; P = 0·15) were similar in the two groups of patients. No adverse reactions to platelet administration were observed. In addition, length of stay in the intensive care unit was unaffected by intervention.CONCLUSIONS: For patients planned for open repair of a rAAA, we observed no significant effect of early administration of platelets with regard to post-operative complications and stay in the ICU or in hospital and also no significant effect on mortality.
U2 - 10.1111/tme.12540
DO - 10.1111/tme.12540
M3 - Journal article
VL - 28
SP - 386
EP - 391
JO - Transfusion Medicine
JF - Transfusion Medicine
SN - 0958-7578
IS - 5
ER -