Adjunctive Monoclonal Antibody Therapy for Pott's Puffy Tumor Complicating CRSwNP: A Case Report

This case report describes the novel use of adjunctive mepolizumab, a monoclonal antibody, in the management of a Pott's Puffy Tumor (PPT) in a 62-year-old male with chronic rhinosinusitis with nasal polyps (CRSwNP). Following extensive surgery to establish drainage, mepolizumab was administered postoperatively to mitigate the risk of bony restenosis and polyp recurrence. Two years after the surgery, the patient showed sustained symptom relief and a patent frontal sinus drainage pathway, suggesting that this therapy may be a valuable addition for complex CRSwNP cases complicated by PPT.