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Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

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Harvard

Mustieles, V, Pérez-Carrascosa, FM, León, J, Lange, T, Bonde, J-P, Gómez-Peña, C, Artacho-Cordón, F, Barrios-Rodríguez, R, Olmedo-Requena, R, Expósito, J, Jiménez-Moleón, JJ & Arrebola, JP 2021, 'Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer', Environmental Science & Technology, bind 55, nr. 14, s. 9926-9937. https://doi.org/10.1021/acs.est.0c08180

APA

Mustieles, V., Pérez-Carrascosa, F. M., León, J., Lange, T., Bonde, J-P., Gómez-Peña, C., Artacho-Cordón, F., Barrios-Rodríguez, R., Olmedo-Requena, R., Expósito, J., Jiménez-Moleón, J. J., & Arrebola, J. P. (2021). Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer. Environmental Science & Technology, 55(14), 9926-9937. https://doi.org/10.1021/acs.est.0c08180

CBE

Mustieles V, Pérez-Carrascosa FM, León J, Lange T, Bonde J-P, Gómez-Peña C, Artacho-Cordón F, Barrios-Rodríguez R, Olmedo-Requena R, Expósito J, Jiménez-Moleón JJ, Arrebola JP. 2021. Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer. Environmental Science & Technology. 55(14):9926-9937. https://doi.org/10.1021/acs.est.0c08180

MLA

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Author

Mustieles, Vicente ; Pérez-Carrascosa, Francisco M ; León, Josefa ; Lange, Theis ; Bonde, Jens-Peter ; Gómez-Peña, Celia ; Artacho-Cordón, Francisco ; Barrios-Rodríguez, Rocío ; Olmedo-Requena, Rocío ; Expósito, José ; Jiménez-Moleón, José J ; Arrebola, Juan P. / Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer. I: Environmental Science & Technology. 2021 ; Bind 55, Nr. 14. s. 9926-9937.

Bibtex

@article{ce87fe2264f7410d958081eb3120aa31,
title = "Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer",
abstract = "We aimed to assess the relationships among the adipose tissue's (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003-2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT's oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies.",
keywords = "Adipose Tissue/metabolism, Adult, Environmental Pollutants/metabolism, Humans, Hydrocarbons, Chlorinated/metabolism, Incidence, Neoplasms/chemically induced, Oxidation-Reduction, Persistent Organic Pollutants, Pesticides/metabolism, Polychlorinated Biphenyls/metabolism, Tumor Microenvironment, organochlorine pesticides, polychlorinated biphenyls, persistent organic pollutants, cancer, oxidative stress",
author = "Vicente Mustieles and P{\'e}rez-Carrascosa, {Francisco M} and Josefa Le{\'o}n and Theis Lange and Jens-Peter Bonde and Celia G{\'o}mez-Pe{\~n}a and Francisco Artacho-Cord{\'o}n and Roc{\'i}o Barrios-Rodr{\'i}guez and Roc{\'i}o Olmedo-Requena and Jos{\'e} Exp{\'o}sito and Jim{\'e}nez-Mole{\'o}n, {Jos{\'e} J} and Arrebola, {Juan P}",
year = "2021",
month = jul,
day = "20",
doi = "10.1021/acs.est.0c08180",
language = "English",
volume = "55",
pages = "9926--9937",
journal = "Environmental Science & Technology",
issn = "0013-936X",
publisher = "American Chemical Society",
number = "14",

}

RIS

TY - JOUR

T1 - Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer

AU - Mustieles, Vicente

AU - Pérez-Carrascosa, Francisco M

AU - León, Josefa

AU - Lange, Theis

AU - Bonde, Jens-Peter

AU - Gómez-Peña, Celia

AU - Artacho-Cordón, Francisco

AU - Barrios-Rodríguez, Rocío

AU - Olmedo-Requena, Rocío

AU - Expósito, José

AU - Jiménez-Moleón, José J

AU - Arrebola, Juan P

PY - 2021/7/20

Y1 - 2021/7/20

N2 - We aimed to assess the relationships among the adipose tissue's (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003-2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT's oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies.

AB - We aimed to assess the relationships among the adipose tissue's (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003-2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT's oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies.

KW - Adipose Tissue/metabolism

KW - Adult

KW - Environmental Pollutants/metabolism

KW - Humans

KW - Hydrocarbons, Chlorinated/metabolism

KW - Incidence

KW - Neoplasms/chemically induced

KW - Oxidation-Reduction

KW - Persistent Organic Pollutants

KW - Pesticides/metabolism

KW - Polychlorinated Biphenyls/metabolism

KW - Tumor Microenvironment

KW - organochlorine pesticides

KW - polychlorinated biphenyls

KW - persistent organic pollutants

KW - cancer

KW - oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=85110292117&partnerID=8YFLogxK

U2 - 10.1021/acs.est.0c08180

DO - 10.1021/acs.est.0c08180

M3 - Journal article

C2 - 34180659

VL - 55

SP - 9926

EP - 9937

JO - Environmental Science & Technology

JF - Environmental Science & Technology

SN - 0013-936X

IS - 14

ER -

ID: 67050803