Adipose tissue expression of IL-18 and HIV-associated lipodystrophy

Birgitte Lindegaard; Ann-Brit Eg Hansen; Henriette Pilegaard; Pernille Keller; Jan Gerstoft; Bente Klarlund Pedersen

doi:10.1097/00002030-200409240-00013

Adipose tissue expression of IL-18 and HIV-associated lipodystrophy

Birgitte Lindegaard, Ann-Brit Eg Hansen, Henriette Pilegaard, Pernille Keller, Jan Gerstoft, Bente Klarlund Pedersen

40 Citationer (Scopus)

Abstract

IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.

Originalsprog	Engelsk
Tidsskrift	AIDS
Vol/bind	18
Udgave nummer	14
Sider (fra-til)	1956-8
Antal sider	3
ISSN	0269-9370
DOI	https://doi.org/10.1097/00002030-200409240-00013
Status	Udgivet - 24 sep. 2004

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title = "Adipose tissue expression of IL-18 and HIV-associated lipodystrophy",

abstract = "IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.",

keywords = "Adipose Tissue/metabolism, Analysis of Variance, Cross-Sectional Studies, HIV-Associated Lipodystrophy Syndrome/metabolism, Humans, Interleukin-18/metabolism, RNA, Messenger/metabolism, Tumor Necrosis Factor-alpha/metabolism",

author = "Birgitte Lindegaard and Hansen, \{Ann-Brit Eg\} and Henriette Pilegaard and Pernille Keller and Jan Gerstoft and Pedersen, \{Bente Klarlund\}",

year = "2004",

month = sep,

day = "24",

doi = "10.1097/00002030-200409240-00013",

language = "English",

volume = "18",

pages = "1956--8",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "14",

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TY - JOUR

T1 - Adipose tissue expression of IL-18 and HIV-associated lipodystrophy

AU - Lindegaard, Birgitte

AU - Hansen, Ann-Brit Eg

AU - Pilegaard, Henriette

AU - Keller, Pernille

AU - Gerstoft, Jan

AU - Pedersen, Bente Klarlund

PY - 2004/9/24

Y1 - 2004/9/24

N2 - IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.

AB - IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.

KW - Adipose Tissue/metabolism

KW - Analysis of Variance

KW - Cross-Sectional Studies

KW - HIV-Associated Lipodystrophy Syndrome/metabolism

KW - Humans

KW - Interleukin-18/metabolism

KW - RNA, Messenger/metabolism

KW - Tumor Necrosis Factor-alpha/metabolism

UR - https://www.scopus.com/pages/publications/4744362281

U2 - 10.1097/00002030-200409240-00013

DO - 10.1097/00002030-200409240-00013

M3 - Journal article

C2 - 15353983

SN - 0269-9370

VL - 18

SP - 1956

EP - 1958

JO - AIDS

JF - AIDS

IS - 14

ER -

Adipose tissue expression of IL-18 and HIV-associated lipodystrophy

Abstract

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