Adipose tissue expression of IL-18 and HIV-associated lipodystrophy

Birgitte Lindegaard, Ann-Brit Eg Hansen, Henriette Pilegaard, Pernille Keller, Jan Gerstoft, Bente Klarlund Pedersen

    39 Citationer (Scopus)

    Abstract

    IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.

    OriginalsprogEngelsk
    TidsskriftAIDS
    Vol/bind18
    Udgave nummer14
    Sider (fra-til)1956-8
    Antal sider3
    ISSN0269-9370
    DOI
    StatusUdgivet - 24 sep. 2004

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