TY - JOUR
T1 - Adipose tissue expression of IL-18 and HIV-associated lipodystrophy
AU - Lindegaard, Birgitte
AU - Hansen, Ann-Brit Eg
AU - Pilegaard, Henriette
AU - Keller, Pernille
AU - Gerstoft, Jan
AU - Pedersen, Bente Klarlund
PY - 2004/9/24
Y1 - 2004/9/24
N2 - IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.
AB - IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.
KW - Adipose Tissue/metabolism
KW - Analysis of Variance
KW - Cross-Sectional Studies
KW - HIV-Associated Lipodystrophy Syndrome/metabolism
KW - Humans
KW - Interleukin-18/metabolism
KW - RNA, Messenger/metabolism
KW - Tumor Necrosis Factor-alpha/metabolism
U2 - 10.1097/00002030-200409240-00013
DO - 10.1097/00002030-200409240-00013
M3 - Journal article
C2 - 15353983
SN - 0269-9370
VL - 18
SP - 1956
EP - 1958
JO - AIDS
JF - AIDS
IS - 14
ER -