TY - JOUR
T1 - Adiponectin and left ventricular structure and function in healthy adults
AU - Kozakova, Michaela
AU - Muscelli, Elza
AU - Flyvbjerg, Allan
AU - Frystyk, Jan
AU - Morizzo, Carmela
AU - Palombo, Carlo
AU - Ferrannini, Ele
PY - 2008/7
Y1 - 2008/7
N2 - CONTEXT: Adiponectin inhibits protein synthesis in cardiac myocytes, thereby opposing the effect of cardiac workload and trophic factors (in particular, insulin) on left ventricular (LV) mass and wall thickness (WT).OBJECTIVE: We tested whether adiponectin and its isoforms are related to LV mass, WT, and function independently of metabolic factors.DESIGN: This was a cross-sectional study.SUBJECTS: The study included 77 healthy volunteers (42 men) aged 30-59 yr with normal LV structure and function.MAIN OUTCOME MEASURES: Insulin response and insulin sensitivity were assessed by oral glucose tolerance test and euglycemic hyperinsulinemic clamp. LV mass, WT, stroke work, chamber function, and myocardial longitudinal function were evaluated by standard Doppler echocardiography and tissue Doppler imaging. Total and molecular isoforms of adiponectin were measured in plasma.RESULTS: By multivariate analysis, independent factors affecting LV mass were sex, body mass index, stroke work, and current smoking (R(2) = 0.66). Independent correlates of LV WT were age, stroke work, and plasma adiponectin (standardized r = 0.28, 0.41, and -0.26, P at least < 0.005, R(2) = 0.48). LV longitudinal late diastolic velocity was independently related to age, body mass index, and adiponectin (standardized r = 0.20, 0.26, -0.33, P at least < 0.05, R(2) = 0.30). High-molecular-weight adiponectin (47% of total), but not lower molecular-weight isoforms, insulin sensitivity, or other metabolic factors, was inversely and independently related to WT (standardized r = -0.27, P < 0.01) and myocardial longitudinal late diastolic velocity (standardized r = -0.28, P < 0.05).CONCLUSION: In healthy subjects, circulating total and high-molecular-weight adiponectin are related to LV WT and diastolic function, independently of age and metabolic factors.
AB - CONTEXT: Adiponectin inhibits protein synthesis in cardiac myocytes, thereby opposing the effect of cardiac workload and trophic factors (in particular, insulin) on left ventricular (LV) mass and wall thickness (WT).OBJECTIVE: We tested whether adiponectin and its isoforms are related to LV mass, WT, and function independently of metabolic factors.DESIGN: This was a cross-sectional study.SUBJECTS: The study included 77 healthy volunteers (42 men) aged 30-59 yr with normal LV structure and function.MAIN OUTCOME MEASURES: Insulin response and insulin sensitivity were assessed by oral glucose tolerance test and euglycemic hyperinsulinemic clamp. LV mass, WT, stroke work, chamber function, and myocardial longitudinal function were evaluated by standard Doppler echocardiography and tissue Doppler imaging. Total and molecular isoforms of adiponectin were measured in plasma.RESULTS: By multivariate analysis, independent factors affecting LV mass were sex, body mass index, stroke work, and current smoking (R(2) = 0.66). Independent correlates of LV WT were age, stroke work, and plasma adiponectin (standardized r = 0.28, 0.41, and -0.26, P at least < 0.005, R(2) = 0.48). LV longitudinal late diastolic velocity was independently related to age, body mass index, and adiponectin (standardized r = 0.20, 0.26, -0.33, P at least < 0.05, R(2) = 0.30). High-molecular-weight adiponectin (47% of total), but not lower molecular-weight isoforms, insulin sensitivity, or other metabolic factors, was inversely and independently related to WT (standardized r = -0.27, P < 0.01) and myocardial longitudinal late diastolic velocity (standardized r = -0.28, P < 0.05).CONCLUSION: In healthy subjects, circulating total and high-molecular-weight adiponectin are related to LV WT and diastolic function, independently of age and metabolic factors.
KW - Adiponectin
KW - Adult
KW - Cross-Sectional Studies
KW - Diastole
KW - Female
KW - Heart Ventricles
KW - Humans
KW - Hypertrophy, Left Ventricular
KW - Insulin Resistance
KW - Male
KW - Middle Aged
KW - Protein Isoforms
KW - Systole
KW - Ventricular Function, Left
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1210/jc.2007-2580
DO - 10.1210/jc.2007-2580
M3 - Journal article
C2 - 18397982
SN - 0021-972X
VL - 93
SP - 2811
EP - 2818
JO - The Journal of clinical endocrinology and metabolism
JF - The Journal of clinical endocrinology and metabolism
IS - 7
ER -