Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots

Nagendra P Palani, Carla Horvath, Pascal N Timshel, Pytrik Folkertsma, Alexander G B Grønning, Tora I Henriksen, Lone Peijs, Verena H Jensen, Wenfei Sun, Naja Z Jespersen, Christian Wolfrum, Tune H Pers, Søren Nielsen*, Camilla Scheele*

*Corresponding author af dette arbejde
7 Citationer (Scopus)

Abstract

Adipocyte function is a major determinant of metabolic disease, warranting investigations of regulating mechanisms. We show at single-cell resolution that progenitor cells from four human brown and white adipose depots separate into two main cell fates, an adipogenic and a structural branch, developing from a common progenitor. The adipogenic gene signature contains mitochondrial activity genes, and associates with genome-wide association study traits for fat distribution. Based on an extracellular matrix and developmental gene signature, we name the structural branch of cells structural Wnt-regulated adipose tissue-resident (SWAT) cells. When stripped from adipogenic cells, SWAT cells display a multipotent phenotype by reverting towards progenitor state or differentiating into new adipogenic cells, dependent on media. Label transfer algorithms recapitulate the cell types in human adipose tissue datasets. In conclusion, we provide a differentiation map of human adipocytes and define the multipotent SWAT cell, providing a new perspective on adipose tissue regulation.

OriginalsprogEngelsk
TidsskriftNature metabolism
Vol/bind5
Udgave nummer6
Sider (fra-til)996-1013
Antal sider18
ISSN2522-5812
DOI
StatusUdgivet - jun. 2023

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