Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin

B Lindegaard; S Ditlevsen; P Plomgaard; B Mittendorfer; B K Pedersen

doi:10.1007/s00125-013-2964-3

Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin

B Lindegaard, S Ditlevsen, P Plomgaard, B Mittendorfer, B K Pedersen

9 Citationer (Scopus)

Abstract

Low-grade inflammation is a feature of chronic diseases such as type 2 diabetes and lipodystrophy. It is associated with abdominal adiposity, increased levels of NEFA, hyperinsulinaemia and low adiponectin levels. However, the causal relationship between impaired metabolism and inflammation is not understood. We explored the anti-lipolytic effect of acipimox and insulin on adiponectin and adipocyte-associated cytokines in patients with lipodystrophy.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	56
Udgave nummer	9
Sider (fra-til)	2034-43
Antal sider	10
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-013-2964-3
Status	Udgivet - sep. 2013

Adgang til dokumentet

10.1007/s00125-013-2964-3

Citationsformater

@article{3487e4986e5640e3bc907d7f34b5e090,

title = "Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin",

abstract = "Low-grade inflammation is a feature of chronic diseases such as type 2 diabetes and lipodystrophy. It is associated with abdominal adiposity, increased levels of NEFA, hyperinsulinaemia and low adiponectin levels. However, the causal relationship between impaired metabolism and inflammation is not understood. We explored the anti-lipolytic effect of acipimox and insulin on adiponectin and adipocyte-associated cytokines in patients with lipodystrophy.",

author = "B Lindegaard and S Ditlevsen and P Plomgaard and B Mittendorfer and Pedersen, {B K}",

year = "2013",

month = sep,

doi = "10.1007/s00125-013-2964-3",

language = "English",

volume = "56",

pages = "2034--43",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "9",

}

TY - JOUR

T1 - Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin

AU - Lindegaard, B

AU - Ditlevsen, S

AU - Plomgaard, P

AU - Mittendorfer, B

AU - Pedersen, B K

PY - 2013/9

Y1 - 2013/9

N2 - Low-grade inflammation is a feature of chronic diseases such as type 2 diabetes and lipodystrophy. It is associated with abdominal adiposity, increased levels of NEFA, hyperinsulinaemia and low adiponectin levels. However, the causal relationship between impaired metabolism and inflammation is not understood. We explored the anti-lipolytic effect of acipimox and insulin on adiponectin and adipocyte-associated cytokines in patients with lipodystrophy.

AB - Low-grade inflammation is a feature of chronic diseases such as type 2 diabetes and lipodystrophy. It is associated with abdominal adiposity, increased levels of NEFA, hyperinsulinaemia and low adiponectin levels. However, the causal relationship between impaired metabolism and inflammation is not understood. We explored the anti-lipolytic effect of acipimox and insulin on adiponectin and adipocyte-associated cytokines in patients with lipodystrophy.

U2 - 10.1007/s00125-013-2964-3

DO - 10.1007/s00125-013-2964-3

M3 - Journal article

C2 - 23811808

SN - 0012-186X

VL - 56

SP - 2034

EP - 2043

JO - Diabetologia

JF - Diabetologia

IS - 9

ER -

Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater