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Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature

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Espersen, ADL, Noren-Nyström, U, Abrahamsson, J, Ha, S-Y, Pronk, CJ, Jahnukainen, K, Jónsson, ÓG, Lausen, B, Palle, J, Zeller, B, Palmqvist, L & Hasle, H 2018, 'Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature' Genes, Chromosomes & Cancer, bind 57, nr. 7, s. 359-365. https://doi.org/10.1002/gcc.22538

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Espersen, Anne Dorte Lerche ; Noren-Nyström, Ulrika ; Abrahamsson, Jonas ; Ha, Shau-Yin ; Pronk, Cornelis Jan ; Jahnukainen, Kirsi ; Jónsson, Ólafur G ; Lausen, Birgitte ; Palle, Josefine ; Zeller, Bernward ; Palmqvist, Lars ; Hasle, Henrik. / Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19 : Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature. I: Genes, Chromosomes & Cancer. 2018 ; Bind 57, Nr. 7. s. 359-365.

Bibtex

@article{7a164051d27c45eb85195d6498d0d5df,
title = "Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature",
abstract = "The t(7;12)(q36;p13) (MNX1/ETV6) is not included in the WHO classification but has been described in up to 30{\%} of acute myeloid leukemia (AML) in children <2 years and associated with a poor prognosis. We present the clinical and cytogenetics characteristics of AML cases with t(7;12)(p36;p13). A literature review identified 35 patients with this translocation, published between 2000 and 2015. Outcome data were available in 22 cases. The NOPHO-AML (Nordic Society for Pediatric Hematology and Oncology) database contained 651 patients with AML from 1993 to 2014 and seven (1.1{\%}) had the translocation. The t(7;12) was only present in patients <2 years of age (median age 6 months) but none was diagnosed as newborn. These patients constituted 4.3{\%} of the patients <2 years of age. There was a strong association with trisomy 19 (literature: 86{\%}, NOPHO: 100{\%}) and +8 (literature: 19{\%}, NOPHO: 14{\%}). Seventeen of 22 patients from the literature with t(7;12) and four of seven patients from the NOPHO database suffered from relapse. The patients with t(7;12) had a 3-year event free survival of 24{\%} (literature) vs. 43{\%} (NOPHO) and a 3-year overall survival of 42{\%} (literature) vs. 100{\%} (NOPHO). None of the NOPHO patients was treated with hematopoietic stem cell transplantation (HSCT) in first complete remission. Relapse was frequent but the salvage rate using HSCT was high. We conclude that t(7;12)(q36;13) is a unique subgroup of childhood AML with presentation before 2 years of age with most cases being associated with +19.",
keywords = "Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 19, Chromosomes, Human, Pair 7, Female, Humans, Infant, Leukemia, Myeloid, Acute/drug therapy, Male, Recurrence, Survival Analysis, Translocation, Genetic, Trisomy",
author = "Espersen, {Anne Dorte Lerche} and Ulrika Noren-Nystr{\"o}m and Jonas Abrahamsson and Shau-Yin Ha and Pronk, {Cornelis Jan} and Kirsi Jahnukainen and J{\'o}nsson, {{\'O}lafur G} and Birgitte Lausen and Josefine Palle and Bernward Zeller and Lars Palmqvist and Henrik Hasle",
note = "{\circledC} 2018 Wiley Periodicals, Inc.",
year = "2018",
month = "7",
doi = "10.1002/gcc.22538",
language = "English",
volume = "57",
pages = "359--365",
journal = "Genes Chromosomes and Cancer",
issn = "1045-2257",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19

T2 - Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature

AU - Espersen, Anne Dorte Lerche

AU - Noren-Nyström, Ulrika

AU - Abrahamsson, Jonas

AU - Ha, Shau-Yin

AU - Pronk, Cornelis Jan

AU - Jahnukainen, Kirsi

AU - Jónsson, Ólafur G

AU - Lausen, Birgitte

AU - Palle, Josefine

AU - Zeller, Bernward

AU - Palmqvist, Lars

AU - Hasle, Henrik

N1 - © 2018 Wiley Periodicals, Inc.

PY - 2018/7

Y1 - 2018/7

N2 - The t(7;12)(q36;p13) (MNX1/ETV6) is not included in the WHO classification but has been described in up to 30% of acute myeloid leukemia (AML) in children <2 years and associated with a poor prognosis. We present the clinical and cytogenetics characteristics of AML cases with t(7;12)(p36;p13). A literature review identified 35 patients with this translocation, published between 2000 and 2015. Outcome data were available in 22 cases. The NOPHO-AML (Nordic Society for Pediatric Hematology and Oncology) database contained 651 patients with AML from 1993 to 2014 and seven (1.1%) had the translocation. The t(7;12) was only present in patients <2 years of age (median age 6 months) but none was diagnosed as newborn. These patients constituted 4.3% of the patients <2 years of age. There was a strong association with trisomy 19 (literature: 86%, NOPHO: 100%) and +8 (literature: 19%, NOPHO: 14%). Seventeen of 22 patients from the literature with t(7;12) and four of seven patients from the NOPHO database suffered from relapse. The patients with t(7;12) had a 3-year event free survival of 24% (literature) vs. 43% (NOPHO) and a 3-year overall survival of 42% (literature) vs. 100% (NOPHO). None of the NOPHO patients was treated with hematopoietic stem cell transplantation (HSCT) in first complete remission. Relapse was frequent but the salvage rate using HSCT was high. We conclude that t(7;12)(q36;13) is a unique subgroup of childhood AML with presentation before 2 years of age with most cases being associated with +19.

AB - The t(7;12)(q36;p13) (MNX1/ETV6) is not included in the WHO classification but has been described in up to 30% of acute myeloid leukemia (AML) in children <2 years and associated with a poor prognosis. We present the clinical and cytogenetics characteristics of AML cases with t(7;12)(p36;p13). A literature review identified 35 patients with this translocation, published between 2000 and 2015. Outcome data were available in 22 cases. The NOPHO-AML (Nordic Society for Pediatric Hematology and Oncology) database contained 651 patients with AML from 1993 to 2014 and seven (1.1%) had the translocation. The t(7;12) was only present in patients <2 years of age (median age 6 months) but none was diagnosed as newborn. These patients constituted 4.3% of the patients <2 years of age. There was a strong association with trisomy 19 (literature: 86%, NOPHO: 100%) and +8 (literature: 19%, NOPHO: 14%). Seventeen of 22 patients from the literature with t(7;12) and four of seven patients from the NOPHO database suffered from relapse. The patients with t(7;12) had a 3-year event free survival of 24% (literature) vs. 43% (NOPHO) and a 3-year overall survival of 42% (literature) vs. 100% (NOPHO). None of the NOPHO patients was treated with hematopoietic stem cell transplantation (HSCT) in first complete remission. Relapse was frequent but the salvage rate using HSCT was high. We conclude that t(7;12)(q36;13) is a unique subgroup of childhood AML with presentation before 2 years of age with most cases being associated with +19.

KW - Chromosomes, Human, Pair 12

KW - Chromosomes, Human, Pair 19

KW - Chromosomes, Human, Pair 7

KW - Female

KW - Humans

KW - Infant

KW - Leukemia, Myeloid, Acute/drug therapy

KW - Male

KW - Recurrence

KW - Survival Analysis

KW - Translocation, Genetic

KW - Trisomy

U2 - 10.1002/gcc.22538

DO - 10.1002/gcc.22538

M3 - Review

VL - 57

SP - 359

EP - 365

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

SN - 1045-2257

IS - 7

ER -

ID: 56424715