Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Axonal transport dysfunction of mitochondria in traumatic brain injury: A novel therapeutic target

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Translating promising strategies for bowel and bladder management in spinal cord injury

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Cutaneous noradrenaline measured by microdialysis in complex regional pain syndrome during whole-body cooling and heating

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Proposed framework for forecasting heat-effects on motor-cognitive performance in the Summer Olympics

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Prolonged facemask use in the heat worsens dyspnea without compromising motor-cognitive performance

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Guidelines for TMS/tES Clinical Services and Research through the COVID-19 Pandemic

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Acute exercise protects newly formed motor memories against rTMS-induced interference targeting primary motor cortex

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Lasse Christiansen
  • Bing Chen
  • Yuming Lei
  • M A Urbin
  • Michael S A Richardson
  • Martin Oudega
  • Milap Sandhu
  • W Zev Rymer
  • Randy D Trumbower
  • Gordon S Mitchell
  • Monica A Perez
Vis graf over relationer

Paired corticospinal-motoneuronal stimulation (PCMS) elicits spinal synaptic plasticity in humans with chronic incomplete cervical spinal cord injury (SCI). Here, we examined whether PCMS-induced plasticity could be potentiated by acute intermittent hypoxia (AIH), a treatment also known to induce spinal synaptic plasticity in humans with chronic incomplete cervical SCI. During PCMS, we used 180 pairs of stimuli where corticospinal volleys evoked by transcranial magnetic stimulation over the hand representation of the primary motor cortex were timed to arrive at corticospinal-motoneuronal synapses of the first dorsal interosseous (FDI) muscle ~1-2 ms before the arrival of antidromic potentials elicited in motoneurons by electrical stimulation of the ulnar nerve. During AIH, participants were exposed to brief alternating episodes of hypoxic inspired gas (1 min episodes of 9% O 2) and room air (1 min episodes of 20.9% O 2). We examined corticospinal function by measuring motor evoked potentials (MEPs) elicited by cortical and subcortical stimulation of corticospinal axons and voluntary motor output in the FDI muscle before and after 30 min of PCMS combined with AIH (PCMS+AIH) or sham AIH (PCMS+sham-AIH). The amplitude of MEPs evoked by magnetic and electrical stimulation increased after both protocols, but most after PCMS+AIH, consistent with the hypothesis that their combined effects arise from spinal plasticity. Both protocols increased electromyographic activity in the FDI muscle to a similar extent. Thus, PCMS effects on spinal synapses of hand motoneurons can be potentiated by AIH. The possibility of different thresholds for physiological vs behavioral gains needs to be considered during combinatorial treatments.

OriginalsprogEngelsk
Artikelnummer113483
TidsskriftExperimental Neurology
Vol/bind335
Sider (fra-til)1-11
Antal sider11
ISSN0014-4886
DOI
StatusUdgivet - jan. 2021

ID: 60933724