Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

Alexander G Mathioudakis; Wim Janssens; Pradeesh Sivapalan; Aran Singanayagam; Mark T Dransfield; Jørgen Vestbo; Jens Ulrik Stæhr Jensen

doi:10.1136/thoraxjnl-2019-214484

Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

Alexander G Mathioudakis, Wim Janssens, Pradeesh Sivapalan, Aran Singanayagam, Mark T Dransfield, Jørgen Vestbo, Jens Ulrik Stæhr Jensen

111 Citationer (Scopus)

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.

Originalsprog	Engelsk
Tidsskrift	Thorax
Vol/bind	75
Udgave nummer	6
Sider (fra-til)	520-527
Antal sider	8
ISSN	0040-6376
DOI	https://doi.org/10.1136/thoraxjnl-2019-214484
Status	Udgivet - jun. 2020

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10.1136/thoraxjnl-2019-214484

Citationsformater

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abstract = "Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.",

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AU - Mathioudakis, Alexander G

AU - Janssens, Wim

AU - Sivapalan, Pradeesh

AU - Singanayagam, Aran

AU - Dransfield, Mark T

AU - Vestbo, Jørgen

AU - Jensen, Jens Ulrik Stæhr

N1 - © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

PY - 2020/6

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N2 - Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.

AB - Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.

KW - Biomarkers

KW - Disease Progression

KW - Humans

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JO - Thorax

JF - Thorax

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Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

Abstract

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