Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Acute ethanol administration reduces the antidote effect of N-acetylcysteine after acetaminophen overdose in mice

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Methylphenidate misuse in adult patients and the impact of therapeutic use

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Time-response relationship of nano and micro particle induced lung inflammation. Quartz as reference compound

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Metronidazole elimination is preserved in the elderly

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Effect of theophylline and salbutamol on hepatic drug metabolism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Influence of age and consumption of tobacco, alcohol and caffeine on antipyrine clearance

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Challenges in conducting paediatric trials with off-patent drugs

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

1. The combined antidote effect of N-acetylcysteine and ethanol on the toxicity of acetaminophen was investigated. 2. Fed male mice were given acetaminophen i.p. (600 mg kg-1) and after 5 min in addition ethanol i.p. (0.2 ml, 19% v/v), N-acetylcysteine i.p. (1.2 g kg-1, 0.2 ml), N-acetylcysteine + ethanol i.p. (same doses as given individually) or saline i.p. (0.4 ml). Survival rates were determined after 24, 48, 72 and 96 h. 3. In the N-acetylcysteine group the survival rate was 85%. This rate was significantly reduced to 43% in the N-acetylcysteine + ethanol group (P = 0.0001). In the groups given ethanol or saline alone only 7% and 3%, respectively, survived 96 h. 4. The data suggest that the protective effect of N-acetylcysteine on acetaminophen-induced toxicity in fed mice is reduced by concomitant administration of ethanol. This may explain the clinical observation that ingestion of ethanol worsens the prognosis after acetaminophen intoxication.

OriginalsprogEngelsk
TidsskriftHuman and Experimental Toxicology
Vol/bind10
Udgave nummer6
Sider (fra-til)431-3
Antal sider3
ISSN0960-3271
StatusUdgivet - nov. 1991

ID: 49583773