Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. A placebo-controlled study

K B Madsen; C Askov-Hansen; R M Naimi; C F Brandt; B Hartmann; Janett Holst; Peter Mortensen; P B Jeppesen

doi:10.1016/j.regpep.2013.03.025

Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. A placebo-controlled study

K B Madsen, C Askov-Hansen, R M Naimi, C F Brandt, B Hartmann, Janett Holst, Peter Mortensen, P B Jeppesen

Afdeling for Hjerne- og Nervesygdomme NEU

78 Citationer (Scopus)

Abstract

The ileocolonic brake is impaired in short bowel syndrome (SBS) patients with distal bowel resections. An attenuated meal-stimulated hormone secretion may cause gastric hypersecretion, rapid gastric and intestinal transit and a poor adaptation. Attempting to restore this ileocolonic brake, this study evaluated the acute effects of continuous intravenous administration of glucagon-like peptide (GLP) 1 and 2, alone or in combination, on gastrointestinal function in SBS patients.

Originalsprog	Engelsk
Tidsskrift	Regulatory Peptides
Vol/bind	184
Sider (fra-til)	30-9
Antal sider	10
ISSN	0167-0115
DOI	https://doi.org/10.1016/j.regpep.2013.03.025
Status	Udgivet - 10 jun. 2013

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10.1016/j.regpep.2013.03.025

Citationsformater

Madsen, K. B., Askov-Hansen, C., Naimi, R. M., Brandt, C. F., Hartmann, B., Holst, J., Mortensen, P., & Jeppesen, P. B. (2013). Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. A placebo-controlled study. Regulatory Peptides, 184, 30-9. https://doi.org/10.1016/j.regpep.2013.03.025

Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. A placebo-controlled study. / Madsen, K B; Askov-Hansen, C; Naimi, R M et al.
I: Regulatory Peptides, Bind 184, 10.06.2013, s. 30-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Madsen, KB, Askov-Hansen, C, Naimi, RM, Brandt, CF, Hartmann, B, Holst, J, Mortensen, P & Jeppesen, PB 2013, 'Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. A placebo-controlled study', Regulatory Peptides, bind 184, s. 30-9. https://doi.org/10.1016/j.regpep.2013.03.025

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abstract = "The ileocolonic brake is impaired in short bowel syndrome (SBS) patients with distal bowel resections. An attenuated meal-stimulated hormone secretion may cause gastric hypersecretion, rapid gastric and intestinal transit and a poor adaptation. Attempting to restore this ileocolonic brake, this study evaluated the acute effects of continuous intravenous administration of glucagon-like peptide (GLP) 1 and 2, alone or in combination, on gastrointestinal function in SBS patients.",

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AU - Madsen, K B

AU - Askov-Hansen, C

AU - Naimi, R M

AU - Brandt, C F

AU - Hartmann, B

AU - Holst, Janett

AU - Mortensen, Peter

AU - Jeppesen, P B

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AB - The ileocolonic brake is impaired in short bowel syndrome (SBS) patients with distal bowel resections. An attenuated meal-stimulated hormone secretion may cause gastric hypersecretion, rapid gastric and intestinal transit and a poor adaptation. Attempting to restore this ileocolonic brake, this study evaluated the acute effects of continuous intravenous administration of glucagon-like peptide (GLP) 1 and 2, alone or in combination, on gastrointestinal function in SBS patients.

U2 - 10.1016/j.regpep.2013.03.025

DO - 10.1016/j.regpep.2013.03.025

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Acute effects of continuous infusions of glucagon-like peptide (GLP)-1, GLP-2 and the combination (GLP-1+GLP-2) on intestinal absorption in short bowel syndrome (SBS) patients. A placebo-controlled study

Abstract

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