Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis

L Andresen; V L Jørgensen; A Perner; A Hansen; J Eugen-Olsen; J Rask-Madsen

doi:10.1136/gut.2003.034165

Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis

L Andresen, V L Jørgensen, A Perner, A Hansen, J Eugen-Olsen, J Rask-Madsen

Klinisk Forskningsafdeling AHH

186 Citationer (Scopus)

Abstract

Expression of inducible nitric oxide synthase (iNOS) is greatly upregulated in the colonic mucosa of patients with collagenous and ulcerative colitis. As the transcription factor nuclear factor kappaB (NFkappaB) is a major inducer of iNOS gene expression, we compared activation and transcriptional activity of NFkappaB in colonic mucosal biopsies from these patients.

Originalsprog	Engelsk
Tidsskrift	Gut
Vol/bind	54
Udgave nummer	4
Sider (fra-til)	503-9
Antal sider	7
ISSN	0017-5749
DOI	https://doi.org/10.1136/gut.2003.034165
Status	Udgivet - 2005

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10.1136/gut.2003.034165

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title = "Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis",

abstract = "Expression of inducible nitric oxide synthase (iNOS) is greatly upregulated in the colonic mucosa of patients with collagenous and ulcerative colitis. As the transcription factor nuclear factor kappaB (NFkappaB) is a major inducer of iNOS gene expression, we compared activation and transcriptional activity of NFkappaB in colonic mucosal biopsies from these patients.",

keywords = "Colitis, Collagenous, Colitis, Ulcerative, DNA-Binding Proteins, Epithelial Cells, Gene Expression Profiling, Humans, I-kappa B Kinase, Intestinal Mucosa, NF-kappa B, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Promoter Regions, Genetic, Protein-Serine-Threonine Kinases, Transcription, Genetic, Translocation, Genetic",

author = "L Andresen and J{\o}rgensen, \{V L\} and A Perner and A Hansen and J Eugen-Olsen and J Rask-Madsen",

year = "2005",

doi = "10.1136/gut.2003.034165",

language = "English",

volume = "54",

pages = "503--9",

journal = "Gut",

issn = "0017-5749",

publisher = "BMJ Publishing Group",

number = "4",

}

TY - JOUR

T1 - Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis

AU - Andresen, L

AU - Jørgensen, V L

AU - Perner, A

AU - Hansen, A

AU - Eugen-Olsen, J

AU - Rask-Madsen, J

PY - 2005

Y1 - 2005

N2 - Expression of inducible nitric oxide synthase (iNOS) is greatly upregulated in the colonic mucosa of patients with collagenous and ulcerative colitis. As the transcription factor nuclear factor kappaB (NFkappaB) is a major inducer of iNOS gene expression, we compared activation and transcriptional activity of NFkappaB in colonic mucosal biopsies from these patients.

AB - Expression of inducible nitric oxide synthase (iNOS) is greatly upregulated in the colonic mucosa of patients with collagenous and ulcerative colitis. As the transcription factor nuclear factor kappaB (NFkappaB) is a major inducer of iNOS gene expression, we compared activation and transcriptional activity of NFkappaB in colonic mucosal biopsies from these patients.

KW - Colitis, Collagenous

KW - Colitis, Ulcerative

KW - DNA-Binding Proteins

KW - Epithelial Cells

KW - Gene Expression Profiling

KW - Humans

KW - I-kappa B Kinase

KW - Intestinal Mucosa

KW - NF-kappa B

KW - Nitric Oxide Synthase

KW - Nitric Oxide Synthase Type II

KW - Promoter Regions, Genetic

KW - Protein-Serine-Threonine Kinases

KW - Transcription, Genetic

KW - Translocation, Genetic

UR - https://www.scopus.com/pages/publications/15444376847

U2 - 10.1136/gut.2003.034165

DO - 10.1136/gut.2003.034165

M3 - Journal article

C2 - 15753535

SN - 0017-5749

VL - 54

SP - 503

EP - 509

JO - Gut

JF - Gut

IS - 4

ER -

Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis

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