Activation-dependent antigenic changes of human C3

P Garred, T E Mollnes, M D Kazatchkine

Abstract

The C3 molecule is crucial in the function of the complement system. It is the only substrate for both the classical and the alternative pathways. Native C3 exhibits no biological activity. Upon activation, biologically active C3 fragments are formed, on which new antigenic determinants appear. Activated C3 express distinct binding sites for other complement proteins and cell surface receptors. Recently, it has been possible to study these neoepitopes with monoclonal antibodies. These antibodies are also found valuable in the detection and quantitation of C3 activation products and C3-containing circulating immune complexes.

OriginalsprogEngelsk
TidsskriftComplement and inflammation
Vol/bind6
Udgave nummer3
Sider (fra-til)205-18
Antal sider14
ISSN1012-8204
DOI
StatusUdgivet - 1989
Udgivet eksterntJa

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