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Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

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@article{5891cdb984fa4121b6e6c299028fdb2f,
title = "Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes",
abstract = "Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porphyromonas gingivalis. Addition of platelets activated by thrombin-receptor-activating peptide enhanced IL-10 production induced by LPS (p",
keywords = "Antigens, CD40, Blood Platelets, CD4-Positive T-Lymphocytes, CD40 Ligand, Cell Proliferation, Cells, Cultured, Humans, Inflammation, Interleukin-10, Lipopolysaccharides, Monocytes, Platelet Activation, Porphyromonas gingivalis, Tetanus Toxin, Thyroglobulin, Tumor Necrosis Factor-alpha",
author = "Sif Gudbrandsdottir and Nielsen, {Claus H}",
year = "2013",
month = "10",
day = "15",
doi = "10.4049/jimmunol.1201103",
language = "English",
volume = "191",
pages = "4059--67",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "8",

}

RIS

TY - JOUR

T1 - Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

AU - Gudbrandsdottir, Sif

AU - Nielsen, Claus H

PY - 2013/10/15

Y1 - 2013/10/15

N2 - Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porphyromonas gingivalis. Addition of platelets activated by thrombin-receptor-activating peptide enhanced IL-10 production induced by LPS (p

AB - Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porphyromonas gingivalis. Addition of platelets activated by thrombin-receptor-activating peptide enhanced IL-10 production induced by LPS (p

KW - Antigens, CD40

KW - Blood Platelets

KW - CD4-Positive T-Lymphocytes

KW - CD40 Ligand

KW - Cell Proliferation

KW - Cells, Cultured

KW - Humans

KW - Inflammation

KW - Interleukin-10

KW - Lipopolysaccharides

KW - Monocytes

KW - Platelet Activation

KW - Porphyromonas gingivalis

KW - Tetanus Toxin

KW - Thyroglobulin

KW - Tumor Necrosis Factor-alpha

U2 - 10.4049/jimmunol.1201103

DO - 10.4049/jimmunol.1201103

M3 - Journal article

VL - 191

SP - 4059

EP - 4067

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 8

ER -

ID: 42807074