Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

Sif Gudbrandsdottir; Claus H Nielsen

doi:10.4049/jimmunol.1201103

Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

Sif Gudbrandsdottir, Claus H Nielsen

Afdeling for Rygkirurgi, Led- og Bindevævssygdomme

110 Citationer (Scopus)

Abstract

Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porphyromonas gingivalis. Addition of platelets activated by thrombin-receptor-activating peptide enhanced IL-10 production induced by LPS (p

Originalsprog	Engelsk
Tidsskrift	Journal of immunology (Baltimore, Md. : 1950)
Vol/bind	191
Udgave nummer	8
Sider (fra-til)	4059-67
Antal sider	9
ISSN	0022-1767
DOI	https://doi.org/10.4049/jimmunol.1201103
Status	Udgivet - 15 okt. 2013

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10.4049/jimmunol.1201103

Citationsformater

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abstract = "Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porphyromonas gingivalis. Addition of platelets activated by thrombin-receptor-activating peptide enhanced IL-10 production induced by LPS (p ",

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T1 - Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

AU - Gudbrandsdottir, Sif

AU - Nielsen, Claus H

PY - 2013/10/15

Y1 - 2013/10/15

N2 - Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porphyromonas gingivalis. Addition of platelets activated by thrombin-receptor-activating peptide enhanced IL-10 production induced by LPS (p

AB - Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porphyromonas gingivalis. Addition of platelets activated by thrombin-receptor-activating peptide enhanced IL-10 production induced by LPS (p

KW - Antigens, CD40

KW - Blood Platelets

KW - CD4-Positive T-Lymphocytes

KW - CD40 Ligand

KW - Cell Proliferation

KW - Cells, Cultured

KW - Humans

KW - Inflammation

KW - Interleukin-10

KW - Lipopolysaccharides

KW - Monocytes

KW - Platelet Activation

KW - Porphyromonas gingivalis

KW - Tetanus Toxin

KW - Thyroglobulin

KW - Tumor Necrosis Factor-alpha

U2 - 10.4049/jimmunol.1201103

DO - 10.4049/jimmunol.1201103

M3 - Journal article

C2 - 24048901

SN - 0022-1767

VL - 191

SP - 4059

EP - 4067

JO - Journal of immunology (Baltimore, Md. : 1950)

JF - Journal of immunology (Baltimore, Md. : 1950)

IS - 8

ER -

Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

Abstract

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