Acid secretory potency and elimination of the 15-leucine gastrin-17 analogue in man

The effect on gastric acid secretion and the elimination of a commercially available synthetic human gastrin analogue (15-Leucine Synthetic Human Gastrin I, 15-LSG) were studied in six healthy human subjects. On a molar basis acid secretory efficacy was approximately four times greater than pentagastrin and secretory potency ten times greater. Elimination of 15-LSG was bi-exponential, with half-lives of 5.2 +/- 0.8 and 25.9 +/- 7.0 min. Metabolic clearance rate was 6.9 +/- 0.4 ml/kg-min and volume of distribution 52 ml/kg.