Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease: a prospective cohort study

Zixuan He; Yuhao Sun; Hanyi Huang; Judith Wellens; Yilong Liu; Lintao Dan; Xixian Ruan; Tian Fu; Zhaoshen Li; Xiaoyan Wang; Xue Li; Susanna C Larsson; Johan Burisch; Jie Chen; Yu Bai; Fernando Magro

doi:10.1097/JS9.0000000000003255

Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease: a prospective cohort study

Zixuan He, Yuhao Sun, Hanyi Huang, Judith Wellens, Yilong Liu, Lintao Dan, Xixian Ruan, Tian Fu, Zhaoshen Li, Xiaoyan Wang, Xue Li, Susanna C Larsson, Johan Burisch, Jie Chen^*, Yu Bai^*, Fernando Magro

^*Corresponding author af dette arbejde

Abstract

BACKGROUND: There is limited consensus on physical activity recommendations for inflammatory bowel disease (IBD) patients due to insufficient high-quality evidence.

METHODS: We collected data from 1303 UK Biobank participants with IBD diagnosis and device-measured physical activity. Moderate-to-vigorous physical activity (MVPA) was classified based on data measured by wrist-worn accelerometers over a 7-day period. MVPA patterns were defined as inactive, active weekend warrior, and regularly active.

RESULTS: During a median follow-up of 7.8 years, 56 incident bowel resection cases and 86 deaths were documented. Compared to those in the lowest tertile, participants in the highest tertile of MVPA duration had lower risks of bowel resection [hazard ratio (HR), 0.44; 95% confidence interval (CI), 0.22-0.86] and mortality (HR, 0.49; 95% CI, 0.27-0.89). MVPA duration showed a linear association with bowel resection, while its dose-response relationship with mortality plateaued at approximately 58 minutes/day. The active weekend warrior pattern was inversely associated with bowel resection (HR, 0.28; 95% CI, 0.12-0.65), and the regularly active pattern was inversely associated with both bowel resection (HR, 0.37; 95% CI, 0.19-0.69) and mortality (HR, 0.53; 95% CI, 0.31-0.91) compared to the inactive group. The findings remained consistent after individually adjusting for C-reactive protein, Charlson Comorbidity Index, disease severity, baseline disease activity status, use of IBD-related medications, and baseline bowel resection history.

CONCLUSION: Longer durations of accelerometer-measured MVPA were associated with reduced bowel resection risk and mortality. For affected individuals, the regularly active pattern may be the optimal choice, although the active weekend warrior pattern still provides health benefits compared to being inactive.

Originalsprog	Engelsk
Tidsskrift	International journal of surgery (London, England)
Vol/bind	111
Udgave nummer	12
Sider (fra-til)	9285-9293
Antal sider	9
ISSN	1743-9159
DOI	https://doi.org/10.1097/JS9.0000000000003255
Status	Udgivet - 1 dec. 2025

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10.1097/JS9.0000000000003255Licens: CC BY

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He, Z., Sun, Y., Huang, H., Wellens, J., Liu, Y., Dan, L., Ruan, X., Fu, T., Li, Z., Wang, X., Li, X., Larsson, S. C., Burisch, J., Chen, J., Bai, Y., & Magro, F. (2025). Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease: a prospective cohort study. International journal of surgery (London, England), 111(12), 9285-9293. https://doi.org/10.1097/JS9.0000000000003255

Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease: a prospective cohort study. / He, Zixuan; Sun, Yuhao; Huang, Hanyi et al.
I: International journal of surgery (London, England), Bind 111, Nr. 12, 01.12.2025, s. 9285-9293.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

He, Z, Sun, Y, Huang, H, Wellens, J, Liu, Y, Dan, L, Ruan, X, Fu, T, Li, Z, Wang, X, Li, X, Larsson, SC, Burisch, J, Chen, J, Bai, Y & Magro, F 2025, 'Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease: a prospective cohort study', International journal of surgery (London, England), bind 111, nr. 12, s. 9285-9293. https://doi.org/10.1097/JS9.0000000000003255

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title = "Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease: a prospective cohort study",

abstract = "BACKGROUND: There is limited consensus on physical activity recommendations for inflammatory bowel disease (IBD) patients due to insufficient high-quality evidence.METHODS: We collected data from 1303 UK Biobank participants with IBD diagnosis and device-measured physical activity. Moderate-to-vigorous physical activity (MVPA) was classified based on data measured by wrist-worn accelerometers over a 7-day period. MVPA patterns were defined as inactive, active weekend warrior, and regularly active.RESULTS: During a median follow-up of 7.8 years, 56 incident bowel resection cases and 86 deaths were documented. Compared to those in the lowest tertile, participants in the highest tertile of MVPA duration had lower risks of bowel resection [hazard ratio (HR), 0.44; 95% confidence interval (CI), 0.22-0.86] and mortality (HR, 0.49; 95% CI, 0.27-0.89). MVPA duration showed a linear association with bowel resection, while its dose-response relationship with mortality plateaued at approximately 58 minutes/day. The active weekend warrior pattern was inversely associated with bowel resection (HR, 0.28; 95% CI, 0.12-0.65), and the regularly active pattern was inversely associated with both bowel resection (HR, 0.37; 95% CI, 0.19-0.69) and mortality (HR, 0.53; 95% CI, 0.31-0.91) compared to the inactive group. The findings remained consistent after individually adjusting for C-reactive protein, Charlson Comorbidity Index, disease severity, baseline disease activity status, use of IBD-related medications, and baseline bowel resection history.CONCLUSION: Longer durations of accelerometer-measured MVPA were associated with reduced bowel resection risk and mortality. For affected individuals, the regularly active pattern may be the optimal choice, although the active weekend warrior pattern still provides health benefits compared to being inactive.",

keywords = "Humans, Female, Male, Accelerometry, Prospective Studies, Exercise/physiology, Middle Aged, Inflammatory Bowel Diseases/mortality, Adult, Aged",

author = "Zixuan He and Yuhao Sun and Hanyi Huang and Judith Wellens and Yilong Liu and Lintao Dan and Xixian Ruan and Tian Fu and Zhaoshen Li and Xiaoyan Wang and Xue Li and Larsson, {Susanna C} and Johan Burisch and Jie Chen and Yu Bai and Fernando Magro",

note = "Copyright {\textcopyright} 2025 The Author(s). Published by Wolters Kluwer Health, Inc.",

year = "2025",

month = dec,

day = "1",

doi = "10.1097/JS9.0000000000003255",

language = "English",

volume = "111",

pages = "9285--9293",

journal = "International journal of surgery (London, England)",

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TY - JOUR

T1 - Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease

T2 - a prospective cohort study

AU - He, Zixuan

AU - Sun, Yuhao

AU - Huang, Hanyi

AU - Wellens, Judith

AU - Liu, Yilong

AU - Dan, Lintao

AU - Ruan, Xixian

AU - Fu, Tian

AU - Li, Zhaoshen

AU - Wang, Xiaoyan

AU - Li, Xue

AU - Larsson, Susanna C

AU - Burisch, Johan

AU - Chen, Jie

AU - Bai, Yu

AU - Magro, Fernando

PY - 2025/12/1

Y1 - 2025/12/1

N2 - BACKGROUND: There is limited consensus on physical activity recommendations for inflammatory bowel disease (IBD) patients due to insufficient high-quality evidence.METHODS: We collected data from 1303 UK Biobank participants with IBD diagnosis and device-measured physical activity. Moderate-to-vigorous physical activity (MVPA) was classified based on data measured by wrist-worn accelerometers over a 7-day period. MVPA patterns were defined as inactive, active weekend warrior, and regularly active.RESULTS: During a median follow-up of 7.8 years, 56 incident bowel resection cases and 86 deaths were documented. Compared to those in the lowest tertile, participants in the highest tertile of MVPA duration had lower risks of bowel resection [hazard ratio (HR), 0.44; 95% confidence interval (CI), 0.22-0.86] and mortality (HR, 0.49; 95% CI, 0.27-0.89). MVPA duration showed a linear association with bowel resection, while its dose-response relationship with mortality plateaued at approximately 58 minutes/day. The active weekend warrior pattern was inversely associated with bowel resection (HR, 0.28; 95% CI, 0.12-0.65), and the regularly active pattern was inversely associated with both bowel resection (HR, 0.37; 95% CI, 0.19-0.69) and mortality (HR, 0.53; 95% CI, 0.31-0.91) compared to the inactive group. The findings remained consistent after individually adjusting for C-reactive protein, Charlson Comorbidity Index, disease severity, baseline disease activity status, use of IBD-related medications, and baseline bowel resection history.CONCLUSION: Longer durations of accelerometer-measured MVPA were associated with reduced bowel resection risk and mortality. For affected individuals, the regularly active pattern may be the optimal choice, although the active weekend warrior pattern still provides health benefits compared to being inactive.

AB - BACKGROUND: There is limited consensus on physical activity recommendations for inflammatory bowel disease (IBD) patients due to insufficient high-quality evidence.METHODS: We collected data from 1303 UK Biobank participants with IBD diagnosis and device-measured physical activity. Moderate-to-vigorous physical activity (MVPA) was classified based on data measured by wrist-worn accelerometers over a 7-day period. MVPA patterns were defined as inactive, active weekend warrior, and regularly active.RESULTS: During a median follow-up of 7.8 years, 56 incident bowel resection cases and 86 deaths were documented. Compared to those in the lowest tertile, participants in the highest tertile of MVPA duration had lower risks of bowel resection [hazard ratio (HR), 0.44; 95% confidence interval (CI), 0.22-0.86] and mortality (HR, 0.49; 95% CI, 0.27-0.89). MVPA duration showed a linear association with bowel resection, while its dose-response relationship with mortality plateaued at approximately 58 minutes/day. The active weekend warrior pattern was inversely associated with bowel resection (HR, 0.28; 95% CI, 0.12-0.65), and the regularly active pattern was inversely associated with both bowel resection (HR, 0.37; 95% CI, 0.19-0.69) and mortality (HR, 0.53; 95% CI, 0.31-0.91) compared to the inactive group. The findings remained consistent after individually adjusting for C-reactive protein, Charlson Comorbidity Index, disease severity, baseline disease activity status, use of IBD-related medications, and baseline bowel resection history.CONCLUSION: Longer durations of accelerometer-measured MVPA were associated with reduced bowel resection risk and mortality. For affected individuals, the regularly active pattern may be the optimal choice, although the active weekend warrior pattern still provides health benefits compared to being inactive.

KW - Humans

KW - Female

KW - Male

KW - Accelerometry

KW - Prospective Studies

KW - Exercise/physiology

KW - Middle Aged

KW - Inflammatory Bowel Diseases/mortality

KW - Adult

KW - Aged

U2 - 10.1097/JS9.0000000000003255

DO - 10.1097/JS9.0000000000003255

M3 - Journal article

C2 - 41186517

SN - 1743-9159

VL - 111

SP - 9285

EP - 9293

JO - International journal of surgery (London, England)

JF - International journal of surgery (London, England)

IS - 12

ER -

Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease: a prospective cohort study

Abstract

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