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Region Hovedstaden - en del af Københavns Universitetshospital

Academic performance in adolescents aged 15-16 years born after Frozen Embryo Transfer compared with fresh embryo transfer: a nationwide registry-based cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


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OBJECTIVE: To assess academic performance in singletons aged 15-16 years conceived after frozen Embryo Transfer (FET) compared with singletons born after fresh embryo transfer (ET) in the Danish birth cohorts born from 1995 to 2001.

DESIGN: Danish national registry-based cohort study.

SETTING: Mean test scores on a national standardised and international comparable grading-scale. Adjustments were made for relevant reproductive and socio-demographic covariates.

POPULATION: All 6,495 singletons conceived after assisted reproductive technology (ART) treatment in Denmark from 1995 to 2001 (FET (n) = 423; fresh ET (n) = 6,072.

METHODS: Comparisons of test score were first made in univariate analysis (Model 1) and secondly in a multivariate linear model (Model 2) adjusting for important covariates such as the occupational and educational level of the parents. Linear mixed models were used to account for the correlation in test scores of siblings for continuous outcome.

MAIN OUTCOME MEASURES: Mean overall test score and test score in Danish, mathematics, English and physics/chemistry.

RESULTS: Crude and adjusted mean test scores were similar for adolescents conceived after FET compared with fresh ET. The crude mean difference was +0.11 (95% CI -0.11;0.34) and the adjusted mean difference was +0.12 (95% CI -0.09;0.34).

CONCLUSIONS: Adolescents conceived after FET had similar academic performance at 15-16 of years of age compared with children conceived after fresh ET. This article is protected by copyright. All rights reserved.

TidsskriftBJOG : an international journal of obstetrics and gynaecology
Udgave nummer2
Sider (fra-til)261-269
StatusUdgivet - jan. 2019

ID: 55376190