Absence of entero- and cardioviral RNA in multiple sclerosis brain tissue

R B Dessau; L P Nielsen; J L Frederiksen

doi:10.1111/j.1600-0404.1997.tb00211.x

Absence of entero- and cardioviral RNA in multiple sclerosis brain tissue

R B Dessau, L P Nielsen, J L Frederiksen

6 Citationer (Scopus)

Abstract

OBJECTIVES: Epidemiological evidence suggests that an infectious agent may be involved in the pathogenesis of multiple sclerosis (MS). Picornaviruses are possible candidates for an etiological agent, because of their neurotropic properties and ability to cause chronic infections.

MATERIALS AND METHODS: Autopsy brain tissue from 25 patients with clinically definite MS and 33 control patients without inflammatory neurological disease was tested with reverse transcription PCR specific for enteroviruses and cardioviruses.

RESULTS: All specimens were found negative.

CONCLUSION: These results do not support the theory of a persisting entero- or cardioviral infection as the cause of Ms as we found no evidence of the presence of entero- or cardioviral genomes in the brains from MS patients.

Originalsprog	Engelsk
Tidsskrift	Acta Neurologica Scandinavica
Vol/bind	95
Udgave nummer	5
Sider (fra-til)	284-6
Antal sider	3
ISSN	0001-6314
DOI	https://doi.org/10.1111/j.1600-0404.1997.tb00211.x
Status	Udgivet - maj 1997
Udgivet eksternt	Ja

Adgang til dokumentet

10.1111/j.1600-0404.1997.tb00211.x

Citationsformater

@article{e57532259db6430fa824ae28e74c5522,

title = "Absence of entero- and cardioviral RNA in multiple sclerosis brain tissue",

abstract = "OBJECTIVES: Epidemiological evidence suggests that an infectious agent may be involved in the pathogenesis of multiple sclerosis (MS). Picornaviruses are possible candidates for an etiological agent, because of their neurotropic properties and ability to cause chronic infections.MATERIALS AND METHODS: Autopsy brain tissue from 25 patients with clinically definite MS and 33 control patients without inflammatory neurological disease was tested with reverse transcription PCR specific for enteroviruses and cardioviruses.RESULTS: All specimens were found negative.CONCLUSION: These results do not support the theory of a persisting entero- or cardioviral infection as the cause of Ms as we found no evidence of the presence of entero- or cardioviral genomes in the brains from MS patients.",

keywords = "Adult, Aged, Brain/pathology, Cardiovirus/isolation & purification, Enterovirus/isolation & purification, Female, Genome, Humans, Male, Middle Aged, Multiple Sclerosis/pathology, Polymerase Chain Reaction, RNA, Messenger, RNA, Viral, Transcription, Genetic",

author = "Dessau, {R B} and Nielsen, {L P} and Frederiksen, {J L}",

year = "1997",

month = may,

doi = "10.1111/j.1600-0404.1997.tb00211.x",

language = "English",

volume = "95",

pages = "284--6",

journal = "Acta Neurologica Scandinavica",

issn = "0001-6314",

publisher = "John Wiley and Sons Inc",

number = "5",

}

TY - JOUR

T1 - Absence of entero- and cardioviral RNA in multiple sclerosis brain tissue

AU - Dessau, R B

AU - Nielsen, L P

AU - Frederiksen, J L

PY - 1997/5

Y1 - 1997/5

N2 - OBJECTIVES: Epidemiological evidence suggests that an infectious agent may be involved in the pathogenesis of multiple sclerosis (MS). Picornaviruses are possible candidates for an etiological agent, because of their neurotropic properties and ability to cause chronic infections.MATERIALS AND METHODS: Autopsy brain tissue from 25 patients with clinically definite MS and 33 control patients without inflammatory neurological disease was tested with reverse transcription PCR specific for enteroviruses and cardioviruses.RESULTS: All specimens were found negative.CONCLUSION: These results do not support the theory of a persisting entero- or cardioviral infection as the cause of Ms as we found no evidence of the presence of entero- or cardioviral genomes in the brains from MS patients.

AB - OBJECTIVES: Epidemiological evidence suggests that an infectious agent may be involved in the pathogenesis of multiple sclerosis (MS). Picornaviruses are possible candidates for an etiological agent, because of their neurotropic properties and ability to cause chronic infections.MATERIALS AND METHODS: Autopsy brain tissue from 25 patients with clinically definite MS and 33 control patients without inflammatory neurological disease was tested with reverse transcription PCR specific for enteroviruses and cardioviruses.RESULTS: All specimens were found negative.CONCLUSION: These results do not support the theory of a persisting entero- or cardioviral infection as the cause of Ms as we found no evidence of the presence of entero- or cardioviral genomes in the brains from MS patients.

KW - Adult

KW - Aged

KW - Brain/pathology

KW - Cardiovirus/isolation & purification

KW - Enterovirus/isolation & purification

KW - Female

KW - Genome

KW - Humans

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/pathology

KW - Polymerase Chain Reaction

KW - RNA, Messenger

KW - RNA, Viral

KW - Transcription, Genetic

U2 - 10.1111/j.1600-0404.1997.tb00211.x

DO - 10.1111/j.1600-0404.1997.tb00211.x

M3 - Journal article

C2 - 9188903

SN - 0001-6314

VL - 95

SP - 284

EP - 286

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

IS - 5

ER -

Absence of entero- and cardioviral RNA in multiple sclerosis brain tissue

Abstract

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