Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Abnormal vaginal bleeding in women of reproductive age treated with edoxaban or warfarin for venous thromboembolism: a post hoc analysis of the Hokusai-VTE study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Pattern of mortality after menopausal hormone therapy: long-term follow up in a population-based cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Short- and long-term outcomes in children born after assisted reproductive technology

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  3. Re: Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Functional neuroimaging of recovery from motor conversion disorder: A case report

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Prevalence and significance of anti-phosphatidylserine antibodies: A pooled analysis in 5992 patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Clinical utility of anti-MOG antibody testing in a Danish cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Antiphospholipid syndrome

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  • Ljj Scheres
  • Mpa Brekelmans
  • W Ageno
  • C Ay
  • H R Büller
  • S Eichinger
  • B A Hutten
  • F A Klok
  • S Middeldorp
  • K Schreiber
  • K Stach
  • M Blondon
  • A Delluc
Vis graf over relationer

OBJECTIVE: To investigate the characteristics and outcome of abnormal vaginal bleeding in women receiving edoxaban or warfarin for treatment of venous thromboembolism (VTE).

DESIGN AND SETTING: Post hoc analysis of the Hokusai-VTE study, a multicentre, randomised, double-blind trial comparing edoxaban with warfarin for acute symptomatic VTE.

POPULATION: Women below 50 years receiving edoxaban or warfarin for treatment of VTE.

METHODS: We collected data on diagnostic measures, treatment, and clinical outcome of abnormal vaginal bleeding events.

MAIN OUTCOME MEASURES: Occurrence of major and clinically relevant nonmajor (CRNM) abnormal vaginal bleeding events.

RESULTS: In all, 628 women aged under 50 years were treated with edoxaban and 665 with warfarin. The rate of abnormal vaginal bleeding was 15/100 person-years (py) (95% CI 11-19) in women receiving edoxaban and 9/100 py (95% CI 6-12) in the warfarin group (hazard ratio: 1.7, 95% CI 1.1-2.5). Major abnormal vaginal bleeding occurred in eight (1.3%) women on edoxaban and in three (0.9%) women receiving warfarin [odds ratio (OR) 2.8; 95% CI 0.8-10.8], and CRNM abnormal vaginal bleeding occurred in 53 (8.4%) women treated with edoxaban and in 37 (5.6%) on warfarin therapy (OR 1.6, 95% CI 1.0-2.4). Over 85% of all vaginal bleeds were characterised by heavy menstrual bleeding. Major bleeds frequently required treatment, and in more than 75% of patients anticoagulant therapy was adjusted. The severity of clinical presentation and course of major and CRNM bleeds was mild in most patients.

CONCLUSIONS: Abnormal vaginal bleeding occurred more frequently in women treated with edoxaban than with warfarin. Reassuringly, most events could be managed conservatively and had a mild outcome.

TWEETABLE ABSTRACT: Abnormal vaginal bleeding occurred more frequently in women treated with edoxaban than with warfarin.

OriginalsprogEngelsk
TidsskriftBJOG : an international journal of obstetrics and gynaecology
Vol/bind125
Udgave nummer12
Sider (fra-til)1581-1589
Antal sider9
ISSN1470-0328
DOI
StatusUdgivet - nov. 2018

ID: 56676647