Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. High-Throughput UHPLC-MS to Screen Metabolites in Feces for Gut Metabolic Health

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Invasiv behandling af idiopatisk intrakraniel hypertension

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  • Anna Viitasalo
  • Theresia M Schnurr
  • Niina Pitkänen
  • Mette Hollensted
  • Tenna R H Nielsen
  • Katja Pahkala
  • Mustafa Atalay
  • Mads V Lind
  • Sami Heikkinen
  • Christine Frithioff-Bøjsøe
  • Cilius E Fonvig
  • Niels Grarup
  • Mika Kähönen
  • Germán D Carrasquilla
  • Anni Larnkjaer
  • Oluf Pedersen
  • Kim F Michaelsen
  • Timo A Lakka
  • Jens-Christian Holm
  • Terho Lehtimäki
  • Olli Raitakari
  • Torben Hansen
  • Tuomas O Kilpeläinen
Vis graf over relationer

BACKGROUND: Mendelian randomization studies in adults suggest that abdominal adiposity is causally associated with increased risk of type 2 diabetes and coronary artery disease in adults, but its causal effect on cardiometabolic risk in children remains unclear.

OBJECTIVE: We aimed to study the causal relation of abdominal adiposity with cardiometabolic risk factors in children by applying Mendelian randomization.

METHODS: We constructed a genetic risk score (GRS) using variants previously associated with waist-to-hip ratio adjusted for BMI (WHRadjBMI) and examined its associations with cardiometabolic factors by linear regression and Mendelian randomization in a meta-analysis of 6 cohorts, including 9895 European children and adolescents aged 3-17 y.

RESULTS: WHRadjBMI GRS was associated with higher WHRadjBMI (β = 0.021 SD/allele; 95% CI: 0.016, 0.026 SD/allele; P = 3 × 10-15) and with unfavorable concentrations of blood lipids (higher LDL cholesterol: β = 0.006 SD/allele; 95% CI: 0.001, 0.011 SD/allele; P = 0.025; lower HDL cholesterol: β = -0.007 SD/allele; 95% CI: -0.012, -0.002 SD/allele; P = 0.009; higher triglycerides: β = 0.007 SD/allele; 95% CI: 0.002, 0.012 SD/allele; P = 0.006). No differences were detected between prepubertal and pubertal/postpubertal children. The WHRadjBMI GRS had a stronger association with fasting insulin in children and adolescents with overweight/obesity (β = 0.016 SD/allele; 95% CI: 0.001, 0.032 SD/allele; P = 0.037) than in those with normal weight (β = -0.002 SD/allele; 95% CI: -0.010, 0.006 SD/allele; P = 0.605) (P for difference = 0.034). In a 2-stage least-squares regression analysis, each genetically instrumented 1-SD increase in WHRadjBMI increased circulating triglycerides by 0.17 mmol/L (0.35 SD, P = 0.040), suggesting that the relation between abdominal adiposity and circulating triglycerides may be causal.

CONCLUSIONS: Abdominal adiposity may have a causal, unfavorable effect on plasma triglycerides and potentially other cardiometabolic risk factors starting in childhood. The results highlight the importance of early weight management through healthy dietary habits and physically active lifestyle among children with a tendency for abdominal adiposity.

TidsskriftThe American journal of clinical nutrition
Udgave nummer5
Sider (fra-til)1079-1087
Antal sider9
StatusUdgivet - 1 nov. 2019

Bibliografisk note

Copyright © American Society for Nutrition 2019.

ID: 57934017