ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

Sharon E Johnatty; Jonathan Beesley; Bo Gao; Xiaoqing Chen; Yi Lu; Matthew H Law; Michelle J Henderson; Amanda J Russell; Ellen L Hedditch; Catherine Emmanuel; Sian Fereday; Penelope M Webb; Ellen L Goode; Robert A Vierkant; Brooke L Fridley; Julie M Cunningham; Peter A Fasching; Matthias W Beckmann; Arif B Ekici; Estrid Hogdall; Susanne K Kjaer; Allan Jensen; Claus Hogdall; Robert James (Jim) Brown; Jim Paul; Sandrina Lambrechts; Evelyn Despierre; Ignace Vergote; Jenny Lester; Beth Y Karlan; Florian Heitz; Andreas du Bois; Philipp Harter; Ira Schwaab; Yukie Bean; Tanja Pejovic; Douglas A Levine; Marc T Goodman; Michael E Camey; Pamela J Thompson; Galina Lurie; Joellen Shildkraut; Andrew Berchuck; Kathryn L Terry; Daniel W Cramer; Murray D Norris; Michelle Haber; Stuart MacGregor; Anna deFazio; Georgia Chenevix-Trench; Australian Ovarian Cancer Study Group

doi:10.1016/j.ygyno.2013.07.107

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

Sharon E Johnatty, Jonathan Beesley, Bo Gao, Xiaoqing Chen, Yi Lu, Matthew H Law, Michelle J Henderson, Amanda J Russell, Ellen L Hedditch, Catherine Emmanuel, Sian Fereday, Penelope M Webb, Ellen L Goode, Robert A Vierkant, Brooke L Fridley, Julie M Cunningham, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Estrid HogdallSusanne K Kjaer, Allan Jensen, Claus Hogdall, Robert James (Jim) Brown, Jim Paul, Sandrina Lambrechts, Evelyn Despierre, Ignace Vergote, Jenny Lester, Beth Y Karlan, Florian Heitz, Andreas du Bois, Philipp Harter, Ira Schwaab, Yukie Bean, Tanja Pejovic, Douglas A Levine, Marc T Goodman, Michael E Camey, Pamela J Thompson, Galina Lurie, Joellen Shildkraut, Andrew Berchuck, Kathryn L Terry, Daniel W Cramer, Murray D Norris, Michelle Haber, Stuart MacGregor, Anna deFazio, Georgia Chenevix-Trench, Australian Ovarian Cancer Study Group

Patologi

58 Citationer (Scopus)

Abstract

ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC).

Originalsprog	Engelsk
Tidsskrift	Gynecologic Oncology
Vol/bind	131
Udgave nummer	1
Sider (fra-til)	8-14
Antal sider	7
ISSN	0090-8258
DOI	https://doi.org/10.1016/j.ygyno.2013.07.107
Status	Udgivet - okt. 2013

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10.1016/j.ygyno.2013.07.107

http://ac.els-cdn.com/S009082581301072X/1-s2.0-S009082581301072X-main.pdf?_tid=0fb4a6dc-840e-11e3-8e8d-00000aab0f01&acdnat=1390468348_32a270515ec53b2090d58517427c9c04

Citationsformater

Johnatty, S. E., Beesley, J., Gao, B., Chen, X., Lu, Y., Law, M. H., Henderson, M. J., Russell, A. J., Hedditch, E. L., Emmanuel, C., Fereday, S., Webb, P. M., Goode, E. L., Vierkant, R. A., Fridley, B. L., Cunningham, J. M., Fasching, P. A., Beckmann, M. W., Ekici, A. B., ... Australian Ovarian Cancer Study Group (2013). ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas. Gynecologic Oncology, 131(1), 8-14. https://doi.org/10.1016/j.ygyno.2013.07.107

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas. / Johnatty, Sharon E; Beesley, Jonathan; Gao, Bo et al.
I: Gynecologic Oncology, Bind 131, Nr. 1, 10.2013, s. 8-14.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Johnatty, SE, Beesley, J, Gao, B, Chen, X, Lu, Y, Law, MH, Henderson, MJ, Russell, AJ, Hedditch, EL, Emmanuel, C, Fereday, S, Webb, PM, Goode, EL, Vierkant, RA, Fridley, BL, Cunningham, JM, Fasching, PA, Beckmann, MW, Ekici, AB, Hogdall, E , Kjaer, SK, Jensen, A, Hogdall, C, Brown, RJ, Paul, J, Lambrechts, S, Despierre, E, Vergote, I, Lester, J, Karlan, BY, Heitz, F, du Bois, A, Harter, P, Schwaab, I, Bean, Y, Pejovic, T, Levine, DA, Goodman, MT, Camey, ME, Thompson, PJ, Lurie, G, Shildkraut, J, Berchuck, A, Terry, KL, Cramer, DW, Norris, MD, Haber, M, MacGregor, S, deFazio, A, Chenevix-Trench, G & Australian Ovarian Cancer Study Group 2013, 'ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas', Gynecologic Oncology, bind 131, nr. 1, s. 8-14. https://doi.org/10.1016/j.ygyno.2013.07.107

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title = "ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas",

abstract = "ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC).",

keywords = "Antineoplastic Combined Chemotherapy Protocols, Carboplatin, Disease Progression, Disease-Free Survival, Drug Resistance, Multiple, Drug Resistance, Neoplasm, Female, Humans, Kaplan-Meier Estimate, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, P-Glycoprotein, Paclitaxel, Pharmacogenetics, Polymorphism, Single Nucleotide, Proportional Hazards Models",

author = "Johnatty, {Sharon E} and Jonathan Beesley and Bo Gao and Xiaoqing Chen and Yi Lu and Law, {Matthew H} and Henderson, {Michelle J} and Russell, {Amanda J} and Hedditch, {Ellen L} and Catherine Emmanuel and Sian Fereday and Webb, {Penelope M} and Goode, {Ellen L} and Vierkant, {Robert A} and Fridley, {Brooke L} and Cunningham, {Julie M} and Fasching, {Peter A} and Beckmann, {Matthias W} and Ekici, {Arif B} and Estrid Hogdall and Kjaer, {Susanne K} and Allan Jensen and Claus Hogdall and Brown, {Robert James (Jim)} and Jim Paul and Sandrina Lambrechts and Evelyn Despierre and Ignace Vergote and Jenny Lester and Karlan, {Beth Y} and Florian Heitz and {du Bois}, Andreas and Philipp Harter and Ira Schwaab and Yukie Bean and Tanja Pejovic and Levine, {Douglas A} and Goodman, {Marc T} and Camey, {Michael E} and Thompson, {Pamela J} and Galina Lurie and Joellen Shildkraut and Andrew Berchuck and Terry, {Kathryn L} and Cramer, {Daniel W} and Norris, {Murray D} and Michelle Haber and Stuart MacGregor and Anna deFazio and Georgia Chenevix-Trench and {Australian Ovarian Cancer Study Group}",

year = "2013",

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doi = "10.1016/j.ygyno.2013.07.107",

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T2 - a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

AU - Johnatty, Sharon E

AU - Beesley, Jonathan

AU - Gao, Bo

AU - Chen, Xiaoqing

AU - Lu, Yi

AU - Law, Matthew H

AU - Henderson, Michelle J

AU - Russell, Amanda J

AU - Hedditch, Ellen L

AU - Emmanuel, Catherine

AU - Fereday, Sian

AU - Webb, Penelope M

AU - Goode, Ellen L

AU - Vierkant, Robert A

AU - Fridley, Brooke L

AU - Cunningham, Julie M

AU - Fasching, Peter A

AU - Beckmann, Matthias W

AU - Ekici, Arif B

AU - Hogdall, Estrid

AU - Kjaer, Susanne K

AU - Jensen, Allan

AU - Hogdall, Claus

AU - Brown, Robert James (Jim)

AU - Paul, Jim

AU - Lambrechts, Sandrina

AU - Despierre, Evelyn

AU - Vergote, Ignace

AU - Lester, Jenny

AU - Karlan, Beth Y

AU - Heitz, Florian

AU - du Bois, Andreas

AU - Harter, Philipp

AU - Schwaab, Ira

AU - Bean, Yukie

AU - Pejovic, Tanja

AU - Levine, Douglas A

AU - Goodman, Marc T

AU - Camey, Michael E

AU - Thompson, Pamela J

AU - Lurie, Galina

AU - Shildkraut, Joellen

AU - Berchuck, Andrew

AU - Terry, Kathryn L

AU - Cramer, Daniel W

AU - Norris, Murray D

AU - Haber, Michelle

AU - MacGregor, Stuart

AU - deFazio, Anna

AU - Chenevix-Trench, Georgia

AU - Australian Ovarian Cancer Study Group

PY - 2013/10

Y1 - 2013/10

N2 - ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC).

AB - ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC).

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Carboplatin

KW - Disease Progression

KW - Disease-Free Survival

KW - Drug Resistance, Multiple

KW - Drug Resistance, Neoplasm

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Neoplasms, Glandular and Epithelial

KW - Ovarian Neoplasms

KW - P-Glycoprotein

KW - Paclitaxel

KW - Pharmacogenetics

KW - Polymorphism, Single Nucleotide

KW - Proportional Hazards Models

U2 - 10.1016/j.ygyno.2013.07.107

DO - 10.1016/j.ygyno.2013.07.107

M3 - Journal article

C2 - 23917080

SN - 0090-8258

VL - 131

SP - 8

EP - 14

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 1

ER -

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

Abstract

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