A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma

Xiangqing Sun; Jaime Vengoechea; Robert Elston; Yanwen Chen; Christopher I Amos; Georgina Armstrong; Jonine L Bernstein; Elizabeth Claus; Faith Davis; Richard S Houlston; Dora Il'yasova; Robert B Jenkins; Christoffer Johansen; Rose Lai; Ching C Lau; Yanhong Liu; Bridget J McCarthy; Sara H Olson; Siegal Sadetzki; Joellen Schildkraut; Sanjay Shete; Robert Yu; Nicholas A Vick; Ryan Merrell; Margaret Wrensch; Ping Yang; Beatrice Melin; Melissa L Bondy; Jill S Barnholtz-Sloan; Gliogene Consortium; Helle Broholm

doi:10.1158/1055-9965.EPI-12-0703

A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma

Xiangqing Sun, Jaime Vengoechea, Robert Elston, Yanwen Chen, Christopher I Amos, Georgina Armstrong, Jonine L Bernstein, Elizabeth Claus, Faith Davis, Richard S Houlston, Dora Il'yasova, Robert B Jenkins, Christoffer Johansen, Rose Lai, Ching C Lau, Yanhong Liu, Bridget J McCarthy, Sara H Olson, Siegal Sadetzki, Joellen SchildkrautSanjay Shete, Robert Yu, Nicholas A Vick, Ryan Merrell, Margaret Wrensch, Ping Yang, Beatrice Melin, Melissa L Bondy, Jill S Barnholtz-Sloan, Gliogene Consortium, Helle Broholm

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19 Citationer (Scopus)

Abstract

We propose a 2-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma.

Originalsprog	Engelsk
Tidsskrift	Cancer Epidemiology, Biomarkers & Prevention
Vol/bind	21
Udgave nummer	12
Sider (fra-til)	2242-51
Antal sider	10
ISSN	1055-9965
DOI	https://doi.org/10.1158/1055-9965.EPI-12-0703
Status	Udgivet - 2012

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10.1158/1055-9965.EPI-12-0703

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Sun, X., Vengoechea, J., Elston, R., Chen, Y., Amos, C. I., Armstrong, G., Bernstein, J. L., Claus, E., Davis, F., Houlston, R. S., Il'yasova, D., Jenkins, R. B., Johansen, C., Lai, R., Lau, C. C., Liu, Y., McCarthy, B. J., Olson, S. H., Sadetzki, S., ... Broholm, H. (2012). A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma. Cancer Epidemiology, Biomarkers & Prevention, 21(12), 2242-51. https://doi.org/10.1158/1055-9965.EPI-12-0703

Sun, X, Vengoechea, J, Elston, R, Chen, Y, Amos, CI, Armstrong, G, Bernstein, JL, Claus, E, Davis, F, Houlston, RS, Il'yasova, D, Jenkins, RB, Johansen, C, Lai, R, Lau, CC, Liu, Y, McCarthy, BJ, Olson, SH, Sadetzki, S, Schildkraut, J, Shete, S, Yu, R, Vick, NA, Merrell, R, Wrensch, M, Yang, P, Melin, B, Bondy, ML, Barnholtz-Sloan, JS, Gliogene Consortium & Broholm, H 2012, 'A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma', Cancer Epidemiology, Biomarkers & Prevention, bind 21, nr. 12, s. 2242-51. https://doi.org/10.1158/1055-9965.EPI-12-0703

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title = "A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma",

abstract = "We propose a 2-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma.",

author = "Xiangqing Sun and Jaime Vengoechea and Robert Elston and Yanwen Chen and Amos, {Christopher I} and Georgina Armstrong and Bernstein, {Jonine L} and Elizabeth Claus and Faith Davis and Houlston, {Richard S} and Dora Il'yasova and Jenkins, {Robert B} and Christoffer Johansen and Rose Lai and Lau, {Ching C} and Yanhong Liu and McCarthy, {Bridget J} and Olson, {Sara H} and Siegal Sadetzki and Joellen Schildkraut and Sanjay Shete and Robert Yu and Vick, {Nicholas A} and Ryan Merrell and Margaret Wrensch and Ping Yang and Beatrice Melin and Bondy, {Melissa L} and Barnholtz-Sloan, {Jill S} and {Gliogene Consortium} and Helle Broholm",

year = "2012",

doi = "10.1158/1055-9965.EPI-12-0703",

language = "English",

volume = "21",

pages = "2242--51",

journal = "Cancer Epidemiology, Biomarkers & Prevention",

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TY - JOUR

T1 - A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma

AU - Sun, Xiangqing

AU - Vengoechea, Jaime

AU - Elston, Robert

AU - Chen, Yanwen

AU - Amos, Christopher I

AU - Armstrong, Georgina

AU - Bernstein, Jonine L

AU - Claus, Elizabeth

AU - Davis, Faith

AU - Houlston, Richard S

AU - Il'yasova, Dora

AU - Jenkins, Robert B

AU - Johansen, Christoffer

AU - Lai, Rose

AU - Lau, Ching C

AU - Liu, Yanhong

AU - McCarthy, Bridget J

AU - Olson, Sara H

AU - Sadetzki, Siegal

AU - Schildkraut, Joellen

AU - Shete, Sanjay

AU - Yu, Robert

AU - Vick, Nicholas A

AU - Merrell, Ryan

AU - Wrensch, Margaret

AU - Yang, Ping

AU - Melin, Beatrice

AU - Bondy, Melissa L

AU - Barnholtz-Sloan, Jill S

AU - Gliogene Consortium

AU - Broholm, Helle

PY - 2012

Y1 - 2012

N2 - We propose a 2-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma.

AB - We propose a 2-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma.

U2 - 10.1158/1055-9965.EPI-12-0703

DO - 10.1158/1055-9965.EPI-12-0703

M3 - Journal article

C2 - 22962404

SN - 1055-9965

VL - 21

SP - 2242

EP - 2251

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

IS - 12

ER -

A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma

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