Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

A total blood volume or more transfused during pregnancy or after childbirth: Individual patient data from six international population-based observational studies

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Prevalence of MRSA nasal carriage among pregnant women in Copenhagen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Histological outcomes in HPV-screened elderly women in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The increasing role of a retained placenta in postpartum blood loss: a cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Survival of ovarian cancer patients in Denmark: Results from the Danish gynaecological cancer group (DGCG) database, 1995-2012

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Translation and validation of the Danish version of the postoperative quality of recovery score QoR-15

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Danish surgeons' views on minimally invasive surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Stephen J McCall
  • Dacia Henriquez
  • Hellen McKinnon Edwards
  • Thomas van den Akker
  • Kitty W M Bloemenkamp
  • Johanna van der Bom
  • Marie-Pierre Bonnet
  • Catherine Deneux-Tharaux
  • Serena Donati
  • Ada Gillissen
  • Jennifer J Kurinczuk
  • Zhuoyang Li
  • Alice Maraschini
  • Aurélien Seco
  • Elizabeth Sullivan
  • Simon Stanworth
  • Marian Knight
Vis graf over relationer

BACKGROUND: This study aimed to compare incidence, management and outcomes of women transfused their blood volume or more within 24 hours during pregnancy or following childbirth.

METHODS: Combined analysis of individual patient data, prospectively collected in six international population-based studies (France, United Kingdom, Italy, Australia, the Netherlands and Denmark). Massive transfusion in major obstetric haemorrhage was defined as transfusion of eight or more units of red blood cells within 24 hours in a pregnant or postpartum woman. Causes, management and outcomes of women with massive transfusion were compared across countries using descriptive statistics.

FINDINGS: The incidence of massive transfusion was approximately 21 women per 100,000 maternities for the United Kingdom, Australia and Italy; by contrast Denmark, the Netherlands and France had incidences of 82, 66 and 69 per 100,000 maternities, respectively. There was large variation in obstetric and haematological management across countries. Fibrinogen products were used in 86% of women in Australia, while the Netherlands and Italy reported lower use at 35-37% of women. Tranexamic acid was used in 75% of women in the Netherlands, but in less than half of women in the UK, Australia and Italy. In all countries, women received large quantities of colloid/crystalloid fluids during resuscitation (>3·5 litres). There was large variation in the use of compression sutures, embolisation and hysterectomy across countries. There was no difference in maternal mortality; however, variable proportions of women had cardiac arrests, renal failure and thrombotic events from 0-16%.

INTERPRETATION: There was considerable variation in the incidence of massive transfusion associated with major obstetric haemorrhage across six high-income countries. There were also large disparities in both transfusion and obstetric management between these countries. There is a requirement for detailed evaluation of evidence underlying current guidance. Furthermore, cross-country comparison may empower countries to reference their clinical care against that of other countries.

OriginalsprogEngelsk
Artikelnummere0244933
TidsskriftPLoS One
Vol/bind16
Udgave nummer1
Sider (fra-til)e0244933
ISSN1932-6203
DOI
StatusUdgivet - 2021

ID: 62019750