Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

A Systematic Review of the Circadian Rhythm of Bone Markers in Blood

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Newly Diagnosed Celiac Disease and Bone Health in Young Adults: A Systematic Literature Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Bone involvement in patients with spondyloarthropathies

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Circadian rhythm of markers of bone turnover in patients with chronic kidney disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Arg82Cys polymorphism of the protein Nepmucin implies a role in HDL metabolism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

There exists a marked circadian variation for several bone markers (BM), which is influenced by endogenous as well as exogenous factors including hormones, physical activity, and fasting. Consequently, was the aim of this review to provide an overview of the knowledge of the circadian variation of BM and which factors influence this rhythmicity. A systematic search of PubMed was performed for studies evaluating the circadian variation of BM and which factors influence this rhythmicity. The studies were screened for eligibility by a set of predetermined criteria including a list of relevant BM and a minimum study duration of 24 h with at least 3 blood samples of which two should be at least 6 h apart. In total were 29 papers included. There exists a marked circadian variation for most BM including Carboxy-terminal Cross-Linked Telopeptide of Type I Collagen (CTX) and osteocalcin (OC) with nighttime or early morning peak. Pro-collagen Type I N-terminal Propeptide (PINP) and PTH also showed circadian rhythm but with less amplitude. The inter-osteoblast-osteoclast regulatory markers such as OPG, RANKL, FGF23, and sclerostin showed no circadian rhythm. The markers were differently affected by exogenous factors like fasting, which greatly reduced the circadian variation of CTX but did not affect PINP or OC. The marked circadian variation and the factors which influence the rhythmicity, e.g., fasting are of great consequence when measuring BM. To reduce variation and heighten validity should circadian variation and fasting be kept in mind when measuring BM.

OriginalsprogEngelsk
TidsskriftCalcified Tissue International
ISSN0171-967X
DOI
StatusE-pub ahead of print - 2022

Bibliografisk note

© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

ID: 75715106