A systematic review of peri-operative melatonin

L P H Andersen, M U Werner, J Rosenberg, I Gögenur

73 Citationer (Scopus)

Abstract

We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.

OriginalsprogEngelsk
TidsskriftAnaesthesia (Oxford)
Vol/bind69
Udgave nummer10
Sider (fra-til)1163-71
Antal sider9
ISSN0003-2409
DOI
StatusUdgivet - okt. 2014

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