Abstract
We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.
Originalsprog | Engelsk |
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Tidsskrift | Anaesthesia (Oxford) |
Vol/bind | 69 |
Udgave nummer | 10 |
Sider (fra-til) | 1163-71 |
Antal sider | 9 |
ISSN | 0003-2409 |
DOI | |
Status | Udgivet - okt. 2014 |