TY - JOUR
T1 - A systematic review of obstetric complications as risk factors for eating disorder and a meta-analysis of delivery method and prematurity
AU - Krug, Isabel
AU - Taborelli, Emma
AU - Sallis, Hannah
AU - Treasure, Janet
AU - Micali, Nadia
N1 - Funding Information:
Dr. Krug was supported by a Marie-Curie Intra European Fellowship within the 7th European Community Framework Programme, as No. 254774 (call reference: FP7-PEOPLE-2009-IEF). This work is produced by Dr Nadia Micali under the terms of a Clinician Scientist Award issued by the NIHR . The views and opinions expressed in this publication are those of the authors and do not necessarily reflect those of the National Health Service (NHS), the NIHR or the DH. H. Sallis was supported by a Research Methods Fellowship from the NIHR .
PY - 2013/1/7
Y1 - 2013/1/7
N2 - Objective: The aim of this study was to systematically review the literature on obstetric factors at birth and their role as risk factors for a subsequent eating disorder (ED) and where possible to perform a meta-analysis of case-control studies of EDs and obstetric complications (OCs). Method: Studies were ascertained by computer searches of electronic databases (Medline, PsycINFO, Web of Science and CINAHL), searches of reference lists and from raw data obtained upon request from the authors. A total of 14 studies were identified for the systematic review, of which 6 were eligible for the subsequent meta-analysis. Of the selected 6 studies, 5 reported on the same OCs, namely vaginal instrumental delivery and prematurity. Accordingly, meta-analyses were run on these two variables. Both analyses were conducted on anorexia nervosa (AN) patients. Results: Findings from the systematic review were conflicting, with some studies reporting a significant relationship between OCs and ED diagnoses and/or ED symptomatology and others refuting it. A non-significant association of instrumental delivery [pooled odds ratio (OR) 1.06, 95%CI: 0.69, 1.65] and prematurity [pooled OR 1.17, 95%CI: 0.91, 1.52] with AN was revealed in our meta-analysis. Conclusion: The current literature on OCs as risk factors for a later ED is contradictory. The range of different occurrences considered as OCs and methodological limitations hinder ultimate conclusions. Upcoming studies should pool datasets together to obtain sufficient power to assess OCs and EDs in combination.
AB - Objective: The aim of this study was to systematically review the literature on obstetric factors at birth and their role as risk factors for a subsequent eating disorder (ED) and where possible to perform a meta-analysis of case-control studies of EDs and obstetric complications (OCs). Method: Studies were ascertained by computer searches of electronic databases (Medline, PsycINFO, Web of Science and CINAHL), searches of reference lists and from raw data obtained upon request from the authors. A total of 14 studies were identified for the systematic review, of which 6 were eligible for the subsequent meta-analysis. Of the selected 6 studies, 5 reported on the same OCs, namely vaginal instrumental delivery and prematurity. Accordingly, meta-analyses were run on these two variables. Both analyses were conducted on anorexia nervosa (AN) patients. Results: Findings from the systematic review were conflicting, with some studies reporting a significant relationship between OCs and ED diagnoses and/or ED symptomatology and others refuting it. A non-significant association of instrumental delivery [pooled odds ratio (OR) 1.06, 95%CI: 0.69, 1.65] and prematurity [pooled OR 1.17, 95%CI: 0.91, 1.52] with AN was revealed in our meta-analysis. Conclusion: The current literature on OCs as risk factors for a later ED is contradictory. The range of different occurrences considered as OCs and methodological limitations hinder ultimate conclusions. Upcoming studies should pool datasets together to obtain sufficient power to assess OCs and EDs in combination.
KW - Anorexia nervosa
KW - Birth complications
KW - Bulimia nervosa
KW - Eating disorders
KW - Obstetric complications
KW - Risk factors
UR - https://www.scopus.com/pages/publications/84871530340
U2 - 10.1016/j.physbeh.2012.11.003
DO - 10.1016/j.physbeh.2012.11.003
M3 - Review
C2 - 23178235
AN - SCOPUS:84871530340
SN - 0031-9384
VL - 109
SP - 51
EP - 62
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 1
ER -