TY - JOUR
T1 - A Systematic Review and Meta-analysis of Animal Studies Investigating the Relationship Between Serum Antibody, T Lymphocytes, and Respiratory Syncytial Virus Disease
AU - McGinley, Joseph
AU - Thwaites, Ryan
AU - Brebner, Will
AU - Greenan-Barrett, Lewis
AU - Aerssens, Jeroen
AU - Öner, Deniz
AU - Bont, Louis
AU - Wildenbeest, Joanne
AU - Martinón-Torres, Federico
AU - Nair, Harish
AU - Pollard, Andrew J
AU - Openshaw, Peter
AU - Drysdale, Simon
AU - REspiratory Syncytial virus Consortium in EUrope (RESCEU) Investigators
A2 - Fischer, Thea Kølsen
N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2022/8/12
Y1 - 2022/8/12
N2 - BACKGROUND: Respiratory syncytial virus (RSV) infections occur in human populations around the globe, causing disease of variable severity, disproportionately affecting infants and older adults (>65 years of age). Immune responses can be protective but also contribute to disease. Experimental studies in animals enable detailed investigation of immune responses, provide insights into clinical questions, and accelerate the development of passive and active vaccination. We aimed to review the role of antibody and T-cell responses in relation to RSV disease severity in animals.METHODS: Systematic review and meta-analysis of animal studies examining the association between T-cell responses/phenotype or antibody titers and severity of RSV disease. The PubMed, Zoological Record, and Embase databases were screened from January 1980 to May 2018 to identify animal studies of RSV infection that assessed serum antibody titer or T lymphocytes with disease severity as an outcome. Sixty-three studies were included in the final review.RESULTS: RSV-specific antibody appears to protect from disease in mice, but such an effect was less evident in bovine RSV. Strong T-cell, Th1, Th2, Th17, CD4/CD8 responses, and weak Treg responses accompany severe disease in mice.CONCLUSIONS: Murine studies suggest that measures of T-lymphocyte activity (particularly CD4 and CD8 T cells) may be predictive biomarkers of severity. Further inquiry is merited to validate these results and assess relevance as biomarkers for human disease.
AB - BACKGROUND: Respiratory syncytial virus (RSV) infections occur in human populations around the globe, causing disease of variable severity, disproportionately affecting infants and older adults (>65 years of age). Immune responses can be protective but also contribute to disease. Experimental studies in animals enable detailed investigation of immune responses, provide insights into clinical questions, and accelerate the development of passive and active vaccination. We aimed to review the role of antibody and T-cell responses in relation to RSV disease severity in animals.METHODS: Systematic review and meta-analysis of animal studies examining the association between T-cell responses/phenotype or antibody titers and severity of RSV disease. The PubMed, Zoological Record, and Embase databases were screened from January 1980 to May 2018 to identify animal studies of RSV infection that assessed serum antibody titer or T lymphocytes with disease severity as an outcome. Sixty-three studies were included in the final review.RESULTS: RSV-specific antibody appears to protect from disease in mice, but such an effect was less evident in bovine RSV. Strong T-cell, Th1, Th2, Th17, CD4/CD8 responses, and weak Treg responses accompany severe disease in mice.CONCLUSIONS: Murine studies suggest that measures of T-lymphocyte activity (particularly CD4 and CD8 T cells) may be predictive biomarkers of severity. Further inquiry is merited to validate these results and assess relevance as biomarkers for human disease.
KW - Aged
KW - Animals
KW - Antibodies, Viral
KW - Biomarkers
KW - CD8-Positive T-Lymphocytes
KW - Cattle
KW - Humans
KW - Infant
KW - Mice
KW - Mice, Inbred BALB C
KW - Respiratory Syncytial Virus Infections
KW - Respiratory Syncytial Viruses
KW - RSV antibody
KW - meta-analysis
KW - systematic review
KW - RSV
KW - T lymphocyte
KW - animal model
KW - disease severity
UR - http://www.scopus.com/inward/record.url?scp=85136341656&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiab370
DO - 10.1093/infdis/jiab370
M3 - Review
C2 - 34522970
SN - 0022-1899
VL - 226
SP - S117-S129
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - Suppl 1
ER -