Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Bone turnover, calcium homeostasis, and vitamin D status in Danish vegans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The efficacy of a high protein/low glycemic index diet intervention in non-obese patients with asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Copenhagen Primary Care Laboratory Pregnancy (CopPreg) database

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Adolescent wine consumption is inversely associated with long-term weight gain: results from follow-up of 20 or 22 years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The fetal brain starts developing early and animal studies have suggested that iron plays several roles for the development, but results from epidemiological studies investigating associations between gestational iron and offspring neurodevelopment are inconsistent.

OBJECTIVE: To systematically examine results from observational studies and RCTs on gestational iron and offspring neurodevelopment, with focus on the importance of four domains: iron status indicators, exposure timing, neurodevelopmental outcomes, and offspring age.

METHODS: PRISMA guidelines were followed. Embase, PsychInfo, Scopus, and The Cochrane library were searched in September 2017 and February 2018. Overall, 3307 articles were identified and 108 retrieved for full-text assessment. Pre-specified eligibility criteria were used to select studies and 27 articles were included;19 observational and 8 RCTs.

RESULTS: Iron status in pregnancy was associated with offspring behavior, cognition, and academic achievement. The direction of associations with behavioral outcomes were unclear and the conclusions related to cognition and academic achievement were based on few studies, only. Little evidence was found for associations with motor development. Observed associations were shown to persist beyond infancy into adolescence, and results depended on iron status indicator type but not on the timing of exposure.

CONCLUSION: We conclude that there is some evidence that low pregnancy iron, possibly particularly in the 3rd trimester, may be associated with adverse offspring neurodevelopment. As most previous research used Hemoglobin, inferring results to iron deficiency should be done with caution. No conclusions could be reached regarding associations beyond early childhood, and supplementation with iron during pregnancy did not seem to influence offspring neurodevelopment.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Nutrition
Vol/bind73
Udgave nummer12
Sider (fra-til)1561-1578
Antal sider18
ISSN0954-3007
DOI
StatusUdgivet - dec. 2019

ID: 58861837