A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22

Torkel Vang; Jimmi Nielsen; Garth L Burn

doi:10.1126/scisignal.aat0936

A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22

Torkel Vang, Jimmi Nielsen, Garth L Burn

Psykiatrisk Center Glostrup

12 Citationer (Scopus)

Abstract

The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.

Originalsprog	Engelsk
Tidsskrift	Cellular Signalling
Vol/bind	11
Udgave nummer	526
ISSN	0898-6568
DOI	https://doi.org/10.1126/scisignal.aat0936
Status	Udgivet - 17 apr. 2018

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title = "A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22",

abstract = "The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new {"}switch-of-function{"} model.",

author = "Torkel Vang and Jimmi Nielsen and Burn, \{Garth L\}",

note = "Copyright {\textcopyright} 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",

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AU - Nielsen, Jimmi

AU - Burn, Garth L

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N2 - The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.

AB - The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.

UR - https://www.scopus.com/pages/publications/85045751792

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DO - 10.1126/scisignal.aat0936

M3 - Review

C2 - 29666305

SN - 0898-6568

VL - 11

JO - Cellular Signalling

JF - Cellular Signalling

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A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22

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