Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

A Selective Biomarker Panel Increases the Reproducibility and the Accuracy in Endometrial Biopsy Diagnosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Neuroendocrine Tumors of the Fallopian Tube: Report of a Case Series and Review of the Literature

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Glycogen Storage Disease Type IV: A Case With Histopathologic Findings in First-Trimester Placental Tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. History of gynecological pathology XXV. Dr Gunnar Teilum

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Expression of epidermal growth factor receptors in human endometrial carcinoma.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  1. Gentagne diploid biparental molae

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Neuroendocrine Tumors of the Fallopian Tube: Report of a Case Series and Review of the Literature

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. The prevalence of EBV and CMV DNA in epithelial ovarian cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Hybrid Capture 2 and cobas human papillomavirus assays perform similarly on SurePath samples from women with abnormalities

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Unexpected uterine malignancy following laparoscopic hysterectomy with morcellation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  • Denis Nastic
  • Emma Shanwell
  • Keng-Ling Wallin
  • Marit Valla
  • Anna Måsbäck
  • Claudia Mateoiu
  • Marianne Lidang
  • Annikki Liakka
  • Elisa Lappi-Blanco
  • Anni Grove
  • Ben Davidson
  • Olli Carpen
  • Bjørn I Bertelsen
  • Julia Bak
  • Anne B Abusland
  • Jonas Selling
  • Joseph W Carlson
Vis graf over relationer

Grading and histologic typing of endometrial cancer in biopsy material has a direct impact on the decision to perform lymphadenectomy and/or omentectomy in many cancer centers. Endometrial biopsies are among the most common general surgical pathology specimens. Multiple studies have shown that biopsy diagnosis suffers from a lack of reproducibility. Although many biomarkers have been proposed, none have been demonstrated to improve the diagnosis in the biopsy setting. In this study, 70 biopsies with endometrial carcinoma were supplemented with a biomarker panel consisting of ER, PR, P53, and DNA ploidy. A representative H&E slide was scanned digitally and made available to 12 gynecologic pathologists in 4 Nordic countries: Finland, Denmark, Sweden, and Norway. Reviewers diagnosed the cases both before and after being provided with the biomarker results. The interobserver percent agreement and Cohen κ improved from 75.8% (κ=0.52, moderate) to 84% (κ=0.68, substantial) with inclusion of the biomarker panel. Agreement with the subsequent hysterectomy diagnosis also improved from 83.6% (κ=0.67) to 88.7% (κ=0.77). There was no statistical improvement between a reflex (84% agreement) and a reflective testing algorithm (82.9% agreement), suggesting that the selective use of biomarkers is appropriate. Difficult cases were almost exclusively high-grade tumors. Finally, a statistical model indicated that only P53 and DNA ploidy, in conjunction with an H&E review, had an impact on the decision to upgrade or downgrade cases.

OriginalsprogEngelsk
TidsskriftInternational journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
Vol/bind36
Udgave nummer4
Sider (fra-til)339-347
Antal sider9
ISSN0277-1691
DOI
StatusUdgivet - jul. 2017

ID: 52665916