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Region Hovedstaden - en del af Københavns Universitetshospital
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A reliability study - strong inter-observer agreement of an expert panel for intestinal ultrasound in ulcerative colitis

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  • Floris De Voogd
  • Rune Wilkens
  • Krisztina Gecse
  • Mariangela Allocca
  • Kerri Novak
  • Cathy Lu
  • Geert D'Haens
  • Christian Maaser
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BACKGROUND: Intestinal ultrasound [IUS] is a promising and non-invasive cross-sectional imaging modality in the diagnosis and monitoring of ulcerative colitis [UC]. Unlike endoscopy, where standardized scoring for evaluation of disease activity is widely used, scoring for UC with IUS is currently unavailable. Therefore, we conducted a study to assess the reliability of IUS in UC among expert sonographists in order to identify robust parameters.

METHODS: Thirty patients with both clinically active [25] and quiescent [five] UC were included. Six expert sonographers first agreed upon key IUS parameters and grading, including bowel wall thickness [BWT], colour Doppler signal [CDS], inflammatory fat [i-fat], loss of bowel wall stratification [BWS], loss of haustrations and presence of lymph nodes. Thirty video-recorded cases were blindly reviewed.

RESULTS: Inter-observer agreement was almost perfect for BWT (intra-class correlation coefficient [ICC]: 0.96) and substantial for CDS [κ = 0.63]. Agreement was moderate for presence of lymph nodes [κ = 0.41] and fair for presence of i-fat [κ = 0.36], BWS [κ = 0.24] and loss of haustrations [κ = 0.26]. Furthermore, there was substantial agreement for presence of disease activity on IUS [κ = 0.77] and almost perfect agreement for disease severity [ICC: 0.93]. Most individual parameters showed a strong association with IUS disease activity as measured by the six readers.

CONCLUSION: IUS is a reliable imaging modality to assess disease activity and severity in UC. Important individual parameters such as BWT and CDS are reliable and could be incorporated in a future UC scoring index. Standardized acquisition and assessment of UC utilizing IUS with established reliability is important to expand the use of IUS globally.

OriginalsprogEngelsk
Artikelnummerjjaa267
TidsskriftJournal of Crohn's & colitis
Vol/bind15
Udgave nummer8
Sider (fra-til)1284-1290
Antal sider7
ISSN1873-9946
DOI
StatusUdgivet - 2 aug. 2021

Bibliografisk note

© The Author(s) 2021. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.

ID: 61910671