A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis

B M Fischer; J Mortensen; S W Langer; A Loft; A K Berthelsen; B I Petersen; G Daugaard; U Lassen; H H Hansen

doi:10.1093/annonc/mdl374

A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis

B M Fischer, J Mortensen, S W Langer, A Loft, A K Berthelsen, B I Petersen, G Daugaard, U Lassen, H H Hansen

138 Citationer (Scopus)

Abstract

BACKGROUND: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.

PATIENTS AND METHODS: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.

RESULTS: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.

CONCLUSION: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.

Originalsprog	Engelsk
Tidsskrift	Annals of Oncology
Vol/bind	18
Udgave nummer	2
Sider (fra-til)	338-45
Antal sider	8
ISSN	0923-7534
DOI	https://doi.org/10.1093/annonc/mdl374
Status	Udgivet - feb. 2007
Udgivet eksternt	Ja

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10.1093/annonc/mdl374

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title = "A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis",

abstract = "BACKGROUND: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.PATIENTS AND METHODS: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.RESULTS: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.CONCLUSION: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.",

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author = "Fischer, {B M} and J Mortensen and Langer, {S W} and A Loft and Berthelsen, {A K} and Petersen, {B I} and G Daugaard and U Lassen and Hansen, {H H}",

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doi = "10.1093/annonc/mdl374",

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TY - JOUR

T1 - A prospective study of PET/CT in initial staging of small-cell lung cancer

T2 - comparison with CT, bone scintigraphy and bone marrow analysis

AU - Fischer, B M

AU - Mortensen, J

AU - Langer, S W

AU - Loft, A

AU - Berthelsen, A K

AU - Petersen, B I

AU - Daugaard, G

AU - Lassen, U

AU - Hansen, H H

PY - 2007/2

Y1 - 2007/2

N2 - BACKGROUND: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.PATIENTS AND METHODS: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.RESULTS: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.CONCLUSION: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.

AB - BACKGROUND: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.PATIENTS AND METHODS: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.RESULTS: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.CONCLUSION: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.

KW - Aged

KW - Bone Marrow/pathology

KW - Bone Neoplasms/diagnostic imaging

KW - Carcinoma, Small Cell/diagnostic imaging

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Lung Neoplasms/diagnostic imaging

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Positron-Emission Tomography

KW - Prospective Studies

KW - Radiopharmaceuticals

KW - Sensitivity and Specificity

KW - Tomography, X-Ray Computed

U2 - 10.1093/annonc/mdl374

DO - 10.1093/annonc/mdl374

M3 - Journal article

C2 - 17060487

SN - 0923-7534

VL - 18

SP - 338

EP - 345

JO - Annals of Oncology

JF - Annals of Oncology

IS - 2

ER -

A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis

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