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A primer on metabolic memory: why existing diabesity treatments fail

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  • Sidar Copur
  • Peter Rossing
  • Baris Afsar
  • Alan A Sag
  • Dimitrie Siriopol
  • Masanari Kuwabara
  • Alberto Ortiz
  • Mehmet Kanbay
Vis graf over relationer

Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.

OriginalsprogEngelsk
TidsskriftClinical kidney journal
Vol/bind14
Udgave nummer3
Sider (fra-til)756-767
Antal sider12
ISSN2048-8505
DOI
StatusUdgivet - mar. 2021

Bibliografisk note

© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.

ID: 67682626