A polymorphism in the angiotensin II type 1 receptor gene has different effects on the risk of diabetic nephropathy in men and women

Anna Möllsten, Nathalie Vionnet, Carol Forsblom, Maija Parkkonen, Lise Tarnow, Samy Hadjadj, Michel Marre, Hans-Henrik Dyring Parving, Per-Henrik Groop

    9 Citationer (Scopus)

    Abstrakt

    BACKGROUND: The etiology of diabetic nephropathy depends partly on genetic factors. Elevated systemic and intraglomerular blood pressure and glomerular filtration rate, partly regulated by the renin-angiotensin system, increase the risk of diabetic nephropathy.

    METHODS: The present case-control study investigated the association of the rs5186 polymorphism, in the angiotensin II type 1 receptor gene (AGTR1), with diabetic nephropathy. The study included 3561 patients with type 1 diabetes from Denmark, Finland, France and Sweden. Microalbuminuria was defined as albumin excretion rate (AER) ≥20 to <200 μg/min or albumin concentration ≥30 to <300 mg/l (n=707), macroalbuminuria was defined as AER≥200 μg/min or ≥300 mg/l (n=1546), and patients with renal replacement therapy were also included in this group. The controls had >15 years diabetes duration, AER <20 μg/min or <30 mg/l, and no antihypertensive treatment (n=1308).

    RESULTS: AA genotype of the rs5186 polymorphism significantly increased the risk of diabetic nephropathy in male patients, OR=1.27 (95% CI=1.02-1.58), P=0.03, adjusted for age at diabetes onset, HbA1c, diabetes duration, smoking and country of origin. Among the women, there were no significant associations between rs5186 and diabetic nephropathy, OR=0.89 (0.71-1.11), P=0.30.

    CONCLUSION: We conclude that the AGTR1 gene may be associated with increased risk of diabetic nephropathy in men with type 1 diabetes.

    OriginalsprogEngelsk
    TidsskriftMolecular Genetics and Metabolism
    Vol/bind103
    Udgave nummer1
    Sider (fra-til)66-70
    Antal sider5
    ISSN1096-7192
    DOI
    StatusUdgivet - maj 2011

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