A placebo-controlled, randomized phase II study of maintenance enzastaurin following whole brain radiation therapy in the treatment of brain metastases from lung cancer

Bjørn H Grønberg; Tudor Ciuleanu; Øystein Fløtten; Aija Knuuttila; Edvard Abel; Seppo W Langer; Kurt Krejcy; Astra M Liepa; Maria Munoz; Marjo Hahka-Kemppinen; Stein Sundstrøm

doi:10.1016/j.lungcan.2012.07.007

A placebo-controlled, randomized phase II study of maintenance enzastaurin following whole brain radiation therapy in the treatment of brain metastases from lung cancer

Bjørn H Grønberg, Tudor Ciuleanu, Øystein Fløtten, Aija Knuuttila, Edvard Abel, Seppo W Langer, Kurt Krejcy, Astra M Liepa, Maria Munoz, Marjo Hahka-Kemppinen, Stein Sundstrøm

22 Citationer (Scopus)

Abstract

Enzastaurin is a protein kinase C inhibitor with anti-tumor activity. This study was designed to determine if maintenance enzastaurin improved the outcome of whole brain radiotherapy (WBRT) in lung cancer (LC) patients with brain metastases (BMs).

Originalsprog	Engelsk
Tidsskrift	Lung Cancer
Vol/bind	78
Udgave nummer	1
Sider (fra-til)	63-9
Antal sider	7
ISSN	0169-5002
DOI	https://doi.org/10.1016/j.lungcan.2012.07.007
Status	Udgivet - 2012

Adgang til dokumentet

10.1016/j.lungcan.2012.07.007

Citationsformater

Grønberg, B. H., Ciuleanu, T., Fløtten, Ø., Knuuttila, A., Abel, E., Langer, S. W., Krejcy, K., Liepa, A. M., Munoz, M., Hahka-Kemppinen, M., & Sundstrøm, S. (2012). A placebo-controlled, randomized phase II study of maintenance enzastaurin following whole brain radiation therapy in the treatment of brain metastases from lung cancer. Lung Cancer, 78(1), 63-9. https://doi.org/10.1016/j.lungcan.2012.07.007

Grønberg, BH, Ciuleanu, T, Fløtten, Ø, Knuuttila, A, Abel, E, Langer, SW, Krejcy, K, Liepa, AM, Munoz, M, Hahka-Kemppinen, M & Sundstrøm, S 2012, 'A placebo-controlled, randomized phase II study of maintenance enzastaurin following whole brain radiation therapy in the treatment of brain metastases from lung cancer', Lung Cancer, bind 78, nr. 1, s. 63-9. https://doi.org/10.1016/j.lungcan.2012.07.007

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title = "A placebo-controlled, randomized phase II study of maintenance enzastaurin following whole brain radiation therapy in the treatment of brain metastases from lung cancer",

abstract = "Enzastaurin is a protein kinase C inhibitor with anti-tumor activity. This study was designed to determine if maintenance enzastaurin improved the outcome of whole brain radiotherapy (WBRT) in lung cancer (LC) patients with brain metastases (BMs).",

author = "Gr{\o}nberg, {Bj{\o}rn H} and Tudor Ciuleanu and {\O}ystein Fl{\o}tten and Aija Knuuttila and Edvard Abel and Langer, {Seppo W} and Kurt Krejcy and Liepa, {Astra M} and Maria Munoz and Marjo Hahka-Kemppinen and Stein Sundstr{\o}m",

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AU - Grønberg, Bjørn H

AU - Ciuleanu, Tudor

AU - Fløtten, Øystein

AU - Knuuttila, Aija

AU - Abel, Edvard

AU - Langer, Seppo W

AU - Krejcy, Kurt

AU - Liepa, Astra M

AU - Munoz, Maria

AU - Hahka-Kemppinen, Marjo

AU - Sundstrøm, Stein

PY - 2012

Y1 - 2012

N2 - Enzastaurin is a protein kinase C inhibitor with anti-tumor activity. This study was designed to determine if maintenance enzastaurin improved the outcome of whole brain radiotherapy (WBRT) in lung cancer (LC) patients with brain metastases (BMs).

AB - Enzastaurin is a protein kinase C inhibitor with anti-tumor activity. This study was designed to determine if maintenance enzastaurin improved the outcome of whole brain radiotherapy (WBRT) in lung cancer (LC) patients with brain metastases (BMs).

U2 - 10.1016/j.lungcan.2012.07.007

DO - 10.1016/j.lungcan.2012.07.007

M3 - Journal article

C2 - 22917813

SN - 0169-5002

VL - 78

SP - 63

EP - 69

JO - Lung Cancer

JF - Lung Cancer

IS - 1

ER -

A placebo-controlled, randomized phase II study of maintenance enzastaurin following whole brain radiation therapy in the treatment of brain metastases from lung cancer

Abstract

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