Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Quantitative single-cell proteomics as a tool to characterize cellular hierarchies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Author Correction: Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  1. Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pharmacogenetic genotype and phenotype frequencies in a large Danish population-based case-cohort sample

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Rates of Incidental Findings in Brain Magnetic Resonance Imaging in Children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Chronic migraine: Genetics or environment?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Xueyi Shen
  • David M. Howard
  • Mark J. Adams
  • W. David Hill
  • Toni Kim Clarke
  • Mark J. Adams
  • Toni Kim Clarke
  • Andrew M. McIntosh
  • Ian J. Deary
  • Naomi R. Wray
  • Stephan Ripke
  • Manuel Mattheisen
  • Maciej Trzaskowski
  • Enda M. Byrne
  • Abdel Abdellaoui
  • Esben Agerbo
  • Tracy M. Air
  • Till F.M. Andlauer
  • Silviu Alin Bacanu
  • Marie Bækvad-Hansen
  • Aartjan T.F. Beekman
  • Tim B. Bigdeli
  • Elisabeth B. Binder
  • Julien Bryois
  • Henriette N. Buttenschøn
  • Jonas Bybjerg-Grauholm
  • Na Cai
  • Enrique Castelao
  • Jane Hvarregaard Christensen
  • Jonathan R.I. Coleman
  • Lucía Colodro-Conde
  • Baptiste Couvy-Duchesne
  • Nick Craddock
  • Gregory E. Crawford
  • Gail Davies
  • Franziska Degenhardt
  • Eske M. Derks
  • Nese Direk
  • Conor V. Dolan
  • Erin C. Dunn
  • Thalia C. Eley
  • Valentina Escott-Price
  • Farnush Farhadi Hassan Kiadeh
  • Hilary K. Finucane
  • Jerome C. Foo
  • Thomas F. Hansen
  • Wesley Thompson
  • Shantel Marie Weinsheimer
  • Merete Nordentoft
  • Thomas Werge
  • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Vis graf over relationer

Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, p FDR  < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, p FDR: 0.049 to 1.28 × 10 -14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.

OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind11
Udgave nummer1
Sider (fra-til)2301
ISSN2041-1723
DOI
StatusUdgivet - 8 maj 2020

ID: 60936025