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Region Hovedstaden - en del af Københavns Universitetshospital
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A personal history of research on microbial biofilms and biofilm infections

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DOI

  1. Bacterial biofilm formation and treatment in soft tissue fillers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Microbial biofilms--the coming of age of a research field

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  3. Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms

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  1. Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

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  3. Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients

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Vis graf over relationer

The observation of aggregated microorganisms surrounded by a self-produced matrix adhering to surfaces or located in tissues or secretions is as old as microbiology, with both Leeuwenhoek and Pasteur describing the phenomenon. In environmental and technical microbiology, biofilms were already shown 80-90 years ago to be important for biofouling on submerged surfaces, e.g. ships. The concept of biofilm infections and their importance in medicine is, however, < 40 years old and was started by Jendresen's observations of acquired dental pellicles and my own observations of heaps of Pseudomonas aeruginosa cells in sputum and lung tissue from chronically infected cystic fibrosis patients. The term biofilm was introduced into medicine in 1985 by Costerton. In the following decades, it became obvious that biofilm infections are widespread in medicine, and their importance is now generally accepted.

OriginalsprogEngelsk
TidsskriftFoodborne Pathogens and Disease
Vol/bind70
Udgave nummer3
Sider (fra-til)205-11
Antal sider7
ISSN1535-3141
DOI
StatusUdgivet - apr. 2014

ID: 44828731