TY - JOUR
T1 - A perioperative layered autologous tissue expansion graft for hollow organ repair
AU - Willacy, Oliver
AU - Juul, Nikolai
AU - Taouzlak, Loai
AU - Chamorro, Clara I
AU - Ajallouiean, Fatemeh
AU - Fossum, Magdalena
N1 - © 2024 The Authors.
PY - 2024/2/15
Y1 - 2024/2/15
N2 - Tissue engineering has not been widely adopted in clinical settings for several reasons, including technical challenges, high costs, and regulatory complexity. Here, we introduce the Perioperative Layered Autologous Tissue Expansion graft (PLATE graft), a composite biomaterial and collagen-reinforced construct with autologous epithelium on one side and smooth muscle tissue on the other. Designed to mimic the structure and function of natural hollow organs, the PLATE graft is unique in that it can be produced in a standard operating theatre and is cost-effective. In this proof-of-principle study, we test its regenerative performance in eight different organs, present biomechanical and permeability tests, and finally explore its in vivo performance in live rabbits.
AB - Tissue engineering has not been widely adopted in clinical settings for several reasons, including technical challenges, high costs, and regulatory complexity. Here, we introduce the Perioperative Layered Autologous Tissue Expansion graft (PLATE graft), a composite biomaterial and collagen-reinforced construct with autologous epithelium on one side and smooth muscle tissue on the other. Designed to mimic the structure and function of natural hollow organs, the PLATE graft is unique in that it can be produced in a standard operating theatre and is cost-effective. In this proof-of-principle study, we test its regenerative performance in eight different organs, present biomechanical and permeability tests, and finally explore its in vivo performance in live rabbits.
UR - http://www.scopus.com/inward/record.url?scp=85184052827&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2024.e25275
DO - 10.1016/j.heliyon.2024.e25275
M3 - Journal article
C2 - 38322882
SN - 2405-8440
VL - 10
SP - e25275
JO - Heliyon
JF - Heliyon
IS - 3
M1 - e25275
ER -